The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
Brief Title: Treatment of Breakpoint Cluster Region-Abelson (BCR-ABL) Negative ALL in Adults
Official Title: Treatment of BCR-ABL Negative ALL in Adults According to MRD and Genetics
Study ID: NCT04179929
Brief Summary: After consolidation therapy adult patients (≥18 yr) with Ph-negative ALL will be treated with continuation chemotherapy or allogeneic hematopoietic stem cell transplantation (alloHSCT) according to both measurable residual disease (MRD) and results of genetic study performed at baseline.
Detailed Description: Patients will be uniformly treated with four drug-induction: vincristine (VCR), prednisone (PDN), pegylated asparaginase (PegASP), daunorubicin (DNR). Resistant patients will receive a second induction with fludarabine, Ara-C, G-Colony-Stimulating Factor (G-CSF) and idarubicin (FLAG-IDA). Patients with adequate MRD clearance after induction will receive 3 blocks of early consolidation. If adequate MRD clearance and good genetic background, the patients will proceed to delayed intensification, reinduction and maintenance. The remaining patients will receive early or delayed alloHSCT.
Minimum Age: 18 Years
Eligible Ages: ADULT
Sex: ALL
Healthy Volunteers: No
Ico-Hugtip, Badalona, Barcelona, Spain
H Albacete, Albacete, , Spain
H. General Univ. de Alicante, Alicante, , Spain
H. General Univ. de Alicante, Alicante, , Spain
Clínica Teknon, Barcelona, , Spain
H del Mar, Barcelona, , Spain
H. Clínic de Barcelona, Barcelona, , Spain
H. del Mar, Barcelona, , Spain
H. Sant Pau, Barcelona, , Spain
H. Vall d'Hebron, Barcelona, , Spain
H. Vall d'Hebron, Barcelona, , Spain
ICO-Duran i Reynals, Bellvitge, , Spain
H Basurto, Bilbao, , Spain
Hu Basurto, Bilbao, , Spain
H. Jerez, Cadiz, , Spain
H. Puerta del Mar, Cadiz, , Spain
H. General de Castellón, Castelló, , Spain
H. San Pedro de Alcántara, Cáceres, , Spain
H. Reina Sofía, Córdoba, , Spain
H. Fuenlabrada, Fuenlabrada, , Spain
H Galdakao, Galdakao, , Spain
H. Univ. De Getafe, Getafe, , Spain
ICO-Dr.Josep Trueta, Girona, , Spain
H. Guadalajara, Guadalajara, , Spain
H Juan Ramón Jiménez, Huelva, , Spain
Complejo Hospitalario Ciudad de Jaén, Jaén, , Spain
H. Jerez de la Frontera, Jerez De La Frontera, , Spain
H. A Coruña, La Coruña, , Spain
H. General Lanzarote, Lanzarote, , Spain
H Dr. Negrín, Las Palmas De Gran Canaria, , Spain
Hospital Insular de Gran Canaria, Las Palmas De Gran Canaria, , Spain
Hu Gran Canarias Dr Negrin, Las Palmas De Gran Canaria, , Spain
H. Arnau De Vilanova, Lleida, , Spain
H. Lucus Augusti, Lugo, , Spain
H. Lucus Augusti, Lugo, , Spain
H. Lucus Augusti, Lugo, , Spain
Fundación Jiménez Díaz, Madrid, , Spain
H La Zarzuela, Madrid, , Spain
H Puerta de Hierro, Madrid, , Spain
H Puerta de Hierro, Madrid, , Spain
H. 12 de Octubre, Madrid, , Spain
H. 12 de Octubre, Madrid, , Spain
H. 12 de Octubre, Madrid, , Spain
H. 12 de Octubre, Madrid, , Spain
H. 12 de Octubre, Madrid, , Spain
H. Clínico de Madrid, Madrid, , Spain
H. Clínico de Madrid, Madrid, , Spain
H. Gregorio Marañón, Madrid, , Spain
H. Gregorio Marañón, Madrid, , Spain
H. Infanta Sofía, Madrid, , Spain
H. Madrid-Norte Sanchinarro, Madrid, , Spain
H. Ramón y Cajal, Madrid, , Spain
H. Ramón y Cajal, Madrid, , Spain
H. Univ La Paz, Madrid, , Spain
Hu Infanta Leonor, Madrid, , Spain
Hu La Princesa, Madrid, , Spain
H. Morales Meseguer, Murcia, , Spain
H. Virgen de la Arrixaca, Murcia, , Spain
H. Virgen de la Arrixaca, Murcia, , Spain
H. Virgen de la Arrixaca, Murcia, , Spain
H. Carlos Haya, Málaga, , Spain
H. Clínico Univ. Virgen de la Victoria, Málaga, , Spain
H. Regional de Málaga, Málaga, , Spain
Complejo Hosp. Univ. de Orense, Orense, , Spain
Complejo Hosp. Univ. de Orense, Orense, , Spain
Complejo Hosp. Univ. de Orense, Orense, , Spain
Complejo Hosp. Univ. de Orense, Orense, , Spain
H. Central de Asturias, Oviedo, , Spain
H Río Carrión, Palencia, , Spain
H. Son Espases, Palma De Mallorca, , Spain
H. Son Llàtzer, Palma De Mallorca, , Spain
Complejo Hospitalario Navarra, Pamplona, , Spain
H. Clínico Univ. de Navarra, Pamplona, , Spain
H. Virgen del Camino, Pamplona, , Spain
Complejo Hospitalario Pontevedra - Hospital Montecelo, Pontevedra, , Spain
H. Parc Taulí, Sabadell, , Spain
H. Clínico Univ. de Salamanca, Salamanca, , Spain
H. Clínico Univ. de Salamanca, Salamanca, , Spain
H Donostia, San Sebastián, , Spain
H Donostia, San Sebastián, , Spain
H Donostia, San Sebastián, , Spain
H Donostia, San Sebastián, , Spain
H. Univ. de Canarias, Santa Cruz De Tenerife, , Spain
H. Marqués de Valdecilla, Santander, , Spain
H. Marqués de Valdecilla, Santander, , Spain
Complejo Hosp. Univ. Santiago de Compostela, Santiago De Compostela, , Spain
Complejo Hosp. Univ. Santiago de Compostela, Santiago De Compostela, , Spain
H. General de Segovia, Segovia, , Spain
H. Universitario de Valme, Sevilla, , Spain
H. Virgen del Rocío, Sevilla, , Spain
ICO-Joan XXIII, Tarragona, , Spain
Mútua de Terrassa, Terrassa, , Spain
H Torrejón, Torrejón De Ardoz, , Spain
H. Verge de la Cinta, Tortosa, , Spain
H. Arnau de Vilanova, Valencia, , Spain
H. Clínico Univ. de Valencia, Valencia, , Spain
H. Dr. Peset, Valencia, , Spain
H. Dr. Peset, Valencia, , Spain
H. General Univ. de Valencia, Valencia, , Spain
H. la Fe, Valencia, , Spain
H. Clínico Universitario de Valladolid, Valladolid, , Spain
H. Río Hortega, Valladolid, , Spain
H. Xeral-Cíes Vigo, Vigo, , Spain
H. Xeral-Cíes Vigo, Vigo, , Spain
H. Virgen de la Concha, Zamora, , Spain
H. Lozano Blesa, Zaragoza, , Spain
H. Miguel Servet, Zaragoza, , Spain
Hospital Nuestra Señora de Sonsoles, Ávila, , Spain