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Spots Global Cancer Trial Database for Treatment of Breakpoint Cluster Region-Abelson (BCR-ABL) Negative ALL in Adults

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Trial Identification

Brief Title: Treatment of Breakpoint Cluster Region-Abelson (BCR-ABL) Negative ALL in Adults

Official Title: Treatment of BCR-ABL Negative ALL in Adults According to MRD and Genetics

Study ID: NCT04179929

Study Description

Brief Summary: After consolidation therapy adult patients (≥18 yr) with Ph-negative ALL will be treated with continuation chemotherapy or allogeneic hematopoietic stem cell transplantation (alloHSCT) according to both measurable residual disease (MRD) and results of genetic study performed at baseline.

Detailed Description: Patients will be uniformly treated with four drug-induction: vincristine (VCR), prednisone (PDN), pegylated asparaginase (PegASP), daunorubicin (DNR). Resistant patients will receive a second induction with fludarabine, Ara-C, G-Colony-Stimulating Factor (G-CSF) and idarubicin (FLAG-IDA). Patients with adequate MRD clearance after induction will receive 3 blocks of early consolidation. If adequate MRD clearance and good genetic background, the patients will proceed to delayed intensification, reinduction and maintenance. The remaining patients will receive early or delayed alloHSCT.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Ico-Hugtip, Badalona, Barcelona, Spain

H Albacete, Albacete, , Spain

H. General Univ. de Alicante, Alicante, , Spain

H. General Univ. de Alicante, Alicante, , Spain

Clínica Teknon, Barcelona, , Spain

H del Mar, Barcelona, , Spain

H. Clínic de Barcelona, Barcelona, , Spain

H. del Mar, Barcelona, , Spain

H. Sant Pau, Barcelona, , Spain

H. Vall d'Hebron, Barcelona, , Spain

H. Vall d'Hebron, Barcelona, , Spain

ICO-Duran i Reynals, Bellvitge, , Spain

H Basurto, Bilbao, , Spain

Hu Basurto, Bilbao, , Spain

H. Jerez, Cadiz, , Spain

H. Puerta del Mar, Cadiz, , Spain

H. General de Castellón, Castelló, , Spain

H. San Pedro de Alcántara, Cáceres, , Spain

H. Reina Sofía, Córdoba, , Spain

H. Fuenlabrada, Fuenlabrada, , Spain

H Galdakao, Galdakao, , Spain

H. Univ. De Getafe, Getafe, , Spain

ICO-Dr.Josep Trueta, Girona, , Spain

H. Guadalajara, Guadalajara, , Spain

H Juan Ramón Jiménez, Huelva, , Spain

Complejo Hospitalario Ciudad de Jaén, Jaén, , Spain

H. Jerez de la Frontera, Jerez De La Frontera, , Spain

H. A Coruña, La Coruña, , Spain

H. General Lanzarote, Lanzarote, , Spain

H Dr. Negrín, Las Palmas De Gran Canaria, , Spain

Hospital Insular de Gran Canaria, Las Palmas De Gran Canaria, , Spain

Hu Gran Canarias Dr Negrin, Las Palmas De Gran Canaria, , Spain

H. Arnau De Vilanova, Lleida, , Spain

H. Lucus Augusti, Lugo, , Spain

H. Lucus Augusti, Lugo, , Spain

H. Lucus Augusti, Lugo, , Spain

Fundación Jiménez Díaz, Madrid, , Spain

H La Zarzuela, Madrid, , Spain

H Puerta de Hierro, Madrid, , Spain

H Puerta de Hierro, Madrid, , Spain

H. 12 de Octubre, Madrid, , Spain

H. 12 de Octubre, Madrid, , Spain

H. 12 de Octubre, Madrid, , Spain

H. 12 de Octubre, Madrid, , Spain

H. 12 de Octubre, Madrid, , Spain

H. Clínico de Madrid, Madrid, , Spain

H. Clínico de Madrid, Madrid, , Spain

H. Gregorio Marañón, Madrid, , Spain

H. Gregorio Marañón, Madrid, , Spain

H. Infanta Sofía, Madrid, , Spain

H. Madrid-Norte Sanchinarro, Madrid, , Spain

H. Ramón y Cajal, Madrid, , Spain

H. Ramón y Cajal, Madrid, , Spain

H. Univ La Paz, Madrid, , Spain

Hu Infanta Leonor, Madrid, , Spain

Hu La Princesa, Madrid, , Spain

H. Morales Meseguer, Murcia, , Spain

H. Virgen de la Arrixaca, Murcia, , Spain

H. Virgen de la Arrixaca, Murcia, , Spain

H. Virgen de la Arrixaca, Murcia, , Spain

H. Carlos Haya, Málaga, , Spain

H. Clínico Univ. Virgen de la Victoria, Málaga, , Spain

H. Regional de Málaga, Málaga, , Spain

Complejo Hosp. Univ. de Orense, Orense, , Spain

Complejo Hosp. Univ. de Orense, Orense, , Spain

Complejo Hosp. Univ. de Orense, Orense, , Spain

Complejo Hosp. Univ. de Orense, Orense, , Spain

H. Central de Asturias, Oviedo, , Spain

H Río Carrión, Palencia, , Spain

H. Son Espases, Palma De Mallorca, , Spain

H. Son Llàtzer, Palma De Mallorca, , Spain

Complejo Hospitalario Navarra, Pamplona, , Spain

H. Clínico Univ. de Navarra, Pamplona, , Spain

H. Virgen del Camino, Pamplona, , Spain

Complejo Hospitalario Pontevedra - Hospital Montecelo, Pontevedra, , Spain

H. Parc Taulí, Sabadell, , Spain

H. Clínico Univ. de Salamanca, Salamanca, , Spain

H. Clínico Univ. de Salamanca, Salamanca, , Spain

H Donostia, San Sebastián, , Spain

H Donostia, San Sebastián, , Spain

H Donostia, San Sebastián, , Spain

H Donostia, San Sebastián, , Spain

H. Univ. de Canarias, Santa Cruz De Tenerife, , Spain

H. Marqués de Valdecilla, Santander, , Spain

H. Marqués de Valdecilla, Santander, , Spain

Complejo Hosp. Univ. Santiago de Compostela, Santiago De Compostela, , Spain

Complejo Hosp. Univ. Santiago de Compostela, Santiago De Compostela, , Spain

H. General de Segovia, Segovia, , Spain

H. Universitario de Valme, Sevilla, , Spain

H. Virgen del Rocío, Sevilla, , Spain

ICO-Joan XXIII, Tarragona, , Spain

Mútua de Terrassa, Terrassa, , Spain

H Torrejón, Torrejón De Ardoz, , Spain

H. Verge de la Cinta, Tortosa, , Spain

H. Arnau de Vilanova, Valencia, , Spain

H. Clínico Univ. de Valencia, Valencia, , Spain

H. Dr. Peset, Valencia, , Spain

H. Dr. Peset, Valencia, , Spain

H. General Univ. de Valencia, Valencia, , Spain

H. la Fe, Valencia, , Spain

H. Clínico Universitario de Valladolid, Valladolid, , Spain

H. Río Hortega, Valladolid, , Spain

H. Xeral-Cíes Vigo, Vigo, , Spain

H. Xeral-Cíes Vigo, Vigo, , Spain

H. Virgen de la Concha, Zamora, , Spain

H. Lozano Blesa, Zaragoza, , Spain

H. Miguel Servet, Zaragoza, , Spain

Hospital Nuestra Señora de Sonsoles, Ávila, , Spain

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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