Spots Global Cancer Trial Database for Treatment of Acute Myeloblastic Leukemia in Younger Patients
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Trial Identification
Brief Title: Treatment of Acute Myeloblastic Leukemia in Younger Patients
Official Title: Prospective Study of the Value of the Cytogenetic and of the Monitoring of the Minimal Residual Disease
Study ID: NCT00390715
Conditions
Interventions
Study Description
Brief Summary: study of the value of the cytogenetics and the monitoring of the residual minimum disease in the standard treatment of acute myeloblastic leukemia.
Detailed Description: The treatment scheme is purely welfare and therefore it does not require any approval of ethical committees for his application. It gathers the basic ideas of the present treatment of the AML, with optional induction according to preference of each center with daunorubicin or Idarubicin (x3) associated to AraC (x7). The patients who reach CR consolidate with an identical cycle to the used one in the induction. Later (if pte has identical donor HLA, and as much it as their doctors has preference by this option) receive allogenic transplant. The other patients who reach CR receive two intensifications, one that AraC to intermediate dose contains and another one with autologous transplant, previous preparation with Busulfán, Etoposide and AraC. Later all antileucemic treatment is suspended until possible relapse. This scheme of treatment is accompanied by a valuation of the quality of the CR with traditional morphology, Immunocytometry and molecular genetic study and of a pursuit of residual minimum disease (EMR) using the same techniques.
Keywords
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Xarxa assistencial de Manresa, Manresa, Barcelona, Spain
Hospital general de Castellón, Castello, Castellón, Spain
Hospital Universitario de Canarias, Tenerife, Islas Canarias, Spain
Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, La Coruña, Spain
Clínica Universitaria de Navarra, Pamplona, Navarra, Spain
Hospital Verge de la Cinta, Tortosa, Tarragona, Spain
Hospital General de Alicante, Alicante, , Spain
Hospital Clínic, Barcelona, , Spain
Hospital de la Santa Creu i Sant Pau, Barcelona, , Spain
Hospital del Mar, Barcelona, , Spain
Hospital Germans Trias i Pujol, Barcelona, , Spain
Hospital vall d'Hebrón, Barcelona, , Spain
Hospital Valle Hebrón-Materno Infantil, Barcelona, , Spain
Complejo Hospitalario de Cáceres, Cáceres, , Spain
Hospital Puerta del Mar, Cádiz, , Spain
Complejo Hospitalario Reina Sofía, Córdoba, , Spain
Hospital Universitario Virgen de las Nieves, Granada, , Spain
Hospital Virgen de las Nieves, Granada, , Spain
Area Hospitalaria Juan Ramón Jimenez, Huelva, , Spain
Hospital general de Jerez de la Frontera, Jerez de la Frontera, , Spain
Hospital Juan Canalejo, La Coruña, , Spain
Hospital Virgen Blanca de León, Leon, , Spain
Fundación Jiménez Díaz, Madrid, , Spain
Hospital Clínico San Carlos de Madrid, Madrid, , Spain
Hospital Doce de Octubre, Madrid, , Spain
Hospital General Universitario Gregorio Marañón, Madrid, Madrid, , Spain
Hospital Universitario de la Princesa, Madrid, , Spain
Hospital General Universitario Morales Meseguer., Murcia, , Spain
. Hospital Clínico Universitario Virgen de la Victoria, Málaga, , Spain
Hospital Central de Asturias, Oviedo, , Spain
Hospital Son Dureta, Palma de Mallorca, , Spain
Hospital Clínico Universitario de Salamanca, Salamanca, , Spain
Hospital Universitario Marqués de Valdecilla, Santander, , Spain
Hospital General de Segovia, Segovia, , Spain
Hospital Universitario Virgen del Rocío, Sevilla, , Spain
Hospital Universitari de Tarragona Joan XXIII, Tarragona, , Spain
Hospital Clínic, Valencia, , Spain
Hospital La Fe, Valencia, , Spain
Hospital Universitario Dr. Peset, Valencia, , Spain
Complejo Hospitalario Xeral-Cies, Vigo, , Spain
Hospital Txagorritxu, Vitoria, , Spain
Hospital Clínico Lozano Blesa, Zaragoza, , Spain
Contact Details
Name: Diaz Mediavilla Joaquin, Dr
Affiliation: Hospital Clínico Universitario San Carlos
Role: STUDY_CHAIR
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