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Brief Title: Phase I Study of S64315 Administred Intravenously in Patients With Acute Myeloid Leukaemia or Myelodysplastic Syndrome
Official Title: Phase I, International, Multicentre, Open-label, Non-randomised, Non-comparative Study of Intravenously Administered S64315, a Mcl-1 Inhibitor, in Patients With Acute Myeloid Leukaemia (AML) or Myelodysplastic Syndrome (MDS)
Study ID: NCT02979366
Brief Summary: The CL1-64315-001 study is a phase I, international, multicentre, open-label, non-randomised, non-comparative study. This study is designed in two parts: one part for dose escalation, one part for dose expansion.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Patient Care Location: Smilow Cancer Hospital at Yale, New Haven, Connecticut, United States
The University of Texas MD Anderson Cancer Center, Department of Leukemia, Division of Cancer Medicine, Houston, Texas, United States
The Alfred Hospital Department of Haematology, Melbourne, , Australia
Royal Melbourne Hospital, Department of Clinical Haematology and BMT Service, Melbourne, , Australia
Institut Paoli-Calmettes Departement d'Hématologie, Marseille, , France
Hôpital Saint-Antoine Département d'Hematologie Clinique et de Thérapie cellulaire, Paris, , France
Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, , France
Hospital Universitario Vall d' Hebron/VHIO Hematology Department, Barcelona, , Spain
Hospital Universitario La Fe Hematology Department, Valencia, , Spain
Name: Andrew WEI
Affiliation: The Alfred Hospital, Melbourne, Victoria
Role: PRINCIPAL_INVESTIGATOR