Spots Global Cancer Trial Database for Phase I Study of UCART123 in Patient With Adverse Genetic Risk Acute Myeloid Leukemia
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Trial Identification
Brief Title: Phase I Study of UCART123 in Patient With Adverse Genetic Risk Acute Myeloid Leukemia
Official Title: Phase I, Open Label Dose-escalation Study to Evaluate the Safety, Expansion, Persistence and Clinical Activity of Multiple Infusions of UCART123 (Allogeneic Engineered T-cells Expressing Anti-CD123 Chimeric Antigen Receptor) in Patients With Adverse Genetic Risk Acute Myeloid Leukaemia
Study ID: NCT04106076
Conditions
Interventions
Study Description
Brief Summary: This is a Phase I, open-label, dose escalation study of UCART123 administered intravenously to patients with newly diagnosed CD123 positive adverse genetic risk acute myeloid leukaemia (AML) defined in the ELN adverse genetic risk group (2017). The purpose of this study is to evaluate the safety and clinical activity of multiple infusions of UCART123 and to determine the Maximum Tolerated Dose (MTD).
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Contact Details
Name: Ghulam Mufti, Pr
Affiliation: Kings college London NHS Foundation Trust
Role: PRINCIPAL_INVESTIGATOR
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