Spots Global Cancer Trial Database for Allogenic Stem Cell Transplantation for Children, Adolescents and Young Adults With Relapsed or Refractory AML
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Trial Identification
Brief Title: Allogenic Stem Cell Transplantation for Children, Adolescents and Young Adults With Relapsed or Refractory AML
Official Title: Allogenic Stem Cell Transplantation for Children, Adolescents and Young Adults With Relapsed or Refractory AML; Multi Center Therapy Concept
Study ID: NCT00606723
Conditions
Study Description
Brief Summary: 1. To evaluate whether stem cell transplantation from a matched sibling donor is equivalent to a matched unrelated donor in in a second complete remission of acute myeloid leukemia (AML). 2. To evaluate whether stem cell transplantation (SCT) after chemotherapy (FLAMSA-schema) increases survival compared to a threshold derived from historical data 3. To evaluate whether SCT from haploidentical donors for children having no matched donor will result in better survival with acceptable toxicity.
Detailed Description: Target variables: * Treatment response * Event Free Survival * Leukemia Free Survival * Graft Versus Host Disease * Regimen related toxicity
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Graz University Hospital, Graz, , Austria
Innsbruck University Hospital, Innsbruck, , Austria
St. Anna Children Hospital, Wien, , Austria
Teaching Hospital Motol, Prag, , Czechia
University Hospital Freiburg, Freiburg, Baden-Württemberg, Germany
Heidelberg University Hospital, Heidelberg, Baden-Württemberg, Germany
University Children's Hospital Tübingen, Tübingen, Baden-Württemberg, Germany
University Children's Hospital Ulm, Ulm, Baden-Württemberg, Germany
University Children's Hospital Erlangen-Nürnberg, Erlangen, Bavaria, Germany
Dr. von Haunersches Kinderspital, München, Bavaria, Germany
University Hospital Würzburg, Würzburg, Bavaria, Germany
J.W. Goethe University Hospital and Faculty of Medicine, Frankfurt, Hesse, Germany
Gießen University Hospital, Gießen, Hesse, Germany
Hannover Medical School, Department of Paediatrics, Paediatric Hematology and Oncology, Hannover, Lower Saxony, Germany
University Hospital Greifswald, Greifswald, Mecklenburg-West Pomerania, Germany
Düsseldorf University Hospital, Düsseldorf, North Rhine-Westphalia, Germany
University Hospital Essen, Essen, North Rhine-Westphalia, Germany
Münster University Hospital, Münster, North Rhine-Westphalia, Germany
University Children's Hospital Halle, Halle, Saxony-Anhalt, Germany
Carl Gustav Carus University Children's Hospital Dresden, Dresden, Saxony, Germany
University Hospital Kiel, Kiel, Schleswig-Holstein, Germany
University Children's Hospital Jena, Jena, Thuringia, Germany
Charité Campus Rudolf Virchow Hospital, Berlin, , Germany
Hamburg-Eppendorf University Hospital, Hamburg, , Germany
Contact Details
Name: Martin Sauer, Prof. Dr.
Affiliation: Hannover Medical School
Role: PRINCIPAL_INVESTIGATOR
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