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Brief Title: Multi-Ctr PII Cmb.Modality Tx Ruxolitinib, Decitabine, and DLI for Post HSCT in AML/MDS
Official Title: A Multi-Center Phase 2 Study of Combined Modality Treatment With Ruxolitinib, Decitabine, and Donor Lymphocyte Infusion for Post-Transplant Relapse of AML or MDS
Study ID: NCT04055844
Brief Summary: This is a multi-center, single-arm, open-label, phase II trial for the frontline treatment of relapsed AML or MDS following allo-HCT. Eligible subjects will receive up to 4 cycles of combined modality treatment. The number of cycles depends on response, toxicity, and the remaining cell dose.
Detailed Description:
Minimum Age: 12 Years
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States
Washington University Medical School, Saint Louis, Missouri, United States
University of Rochester Medical Center, Rochester, New York, United States
Name: Armin Rashidi, MD, PhD
Affiliation: Division of Hematology, Oncology and Transplantation, University of Minnesota
Role: PRINCIPAL_INVESTIGATOR
Name: Mark A Schroeder, M.D.
Affiliation: Washington University School of Medicine
Role: PRINCIPAL_INVESTIGATOR
Name: John F Dipersio, M.D., Ph.D.
Affiliation: Washington University School of Medicine
Role: PRINCIPAL_INVESTIGATOR
Name: Eric Huselton, M.D.
Affiliation: University of Rochester
Role: PRINCIPAL_INVESTIGATOR