Spots Global Cancer Trial Database for Precision-T: A Randomized Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies
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Trial Identification
Brief Title: Precision-T: A Randomized Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies
Official Title: A Randomized Phase III Trial of Patients With Advanced Hematologic Malignancies Undergoing Allogeneic Hematopoietic Cell Transplantation With Either Orca-T, a T-cell-Depleted Graft With Additional Infusion of Conventional T Cells and Regulatory T Cells, or Standard-of-Care Allogeneic Graft
Study ID: NCT05316701
Study Description
Brief Summary: This study will evaluate the safety, tolerability, and efficacy of Orca-T, an allogeneic stem cell and T-cell immunotherapy biologic manufactured for each patient (transplant recipient) from the mobilized peripheral blood of a specific, unique donor. It is composed of purified hematopoietic stem and progenitor cells (HSPCs), purified regulatory T cells (Tregs), and conventional T cells (Tcons) in participants undergoing myeloablative allogeneic hematopoietic cell transplant transplantation for hematologic malignancies. This posting represents the Phase III component of Precision-T. The Precision-T Ph1b component is described under NCT04013685.
Detailed Description: Cross reference NCT04013685
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
City of Hope, Duarte, California, United States
Ronald Reagan UCLA Medical Center, Los Angeles, California, United States
UC Davis, Sacramento, California, United States
Stanford Health Care, Stanford, California, United States
Colorado Blood Cancer Institute, Denver, Colorado, United States
University of Miami Hospital and Clinics - Sylvester Comprehensive Cancer Center, Miami, Florida, United States
Moffitt Cancer Center, Tampa, Florida, United States
Winship Cancer Institute - Emory University, Atlanta, Georgia, United States
University of Chicago, Chicago, Illinois, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
University of Michigan Health System - Michigan Medicine, Ann Arbor, Michigan, United States
Weill Cornell Medicine - New York-Presbyterian Hospital, New York, New York, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Cleveland Clinic, Cleveland, Ohio, United States
OU Health Stephenson Cancer Center, Oklahoma City, Oklahoma, United States
Oregon Health & Sciences University - Knight Cancer Institute, Portland, Oregon, United States
Vanderbilt University, Nashville, Tennessee, United States
Sarah Cannon Research Institute, Nashville, Tennessee, United States
University of Utah, Salt Lake City, Utah, United States
Contact Details
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