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Brief Title: StemRegenin-1 Expanded vs Unexpanded UCB for High Risk Heme Malignancies
Official Title: Single-Center, Open Label, Randomized Trial Comparing StemRegenin-1 Expanded Versus Unmanipulated Umbilical Cord Blood Transplantation In Patients With High-Risk Malignancy
Study ID: NCT02765997
Brief Summary: This is an open label, interventional, randomized phase II trial comparing StemRegenin-1 (SR-1) cultured umbilical cord blood (experimental arm) to unmanipulated umbilical cord blood (standard of care arm) transplantation after a myeloablative CY/FLU/TBI conditioning. A 2:1 randomization will be employed with a higher chance of being assigned to the experimental arm.
Detailed Description:
Minimum Age: 2 Years
Eligible Ages: CHILD, ADULT
Sex: ALL
Healthy Volunteers: No
University of Minnesota Cancer Center, Minneapolis, Minnesota, United States
Name: John Wagner, MD
Affiliation: University of Minnesota
Role: PRINCIPAL_INVESTIGATOR