Spots Global Cancer Trial Database for Study of Periodontitis and Blood Stream Infection in AML Patients Receiving Chemotherapy

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Trial Identification

Brief Title: Study of Periodontitis and Blood Stream Infection in AML Patients Receiving Chemotherapy

Official Title: Effect of Periodontitis on the Risk of Bloodstream Infection During Intensive Chemotherapy in Patients With Acute Myeloid Leukemia

Study ID: NCT04858594

Conditions

Acute Myeloid Leukemia

Interventions

Planned Chemotherapy

Study Description

Brief Summary: This is a prospective, observational study to establish the connection between periodontitis and BSI in AML patients planning to receive intensive chemotherapy.

Detailed Description: Once eligibility is confirmed, participants will undergo a specialized baseline periodontal examination, gingival sulcus microbiota sampling and saliva sample at baseline before starting chemotherapy. Patients will be separated into 2 cohorts, with periodontitis (Arm A) and without periodontitis (Arm B). All patients will receive standard oncologic supportive care including antibiotic prophylaxis. Serum samples will be obtained at baseline, at the onset of neutropenic fever, and weekly until day 28 or discharge (whichever sooner). Study participation will continue during the duration of standard of care chemotherapy for 28 days or until discharge from hospital, whichever later.