Spots Global Cancer Trial Database for Shotgun Sequencing in Diagnosing Febrile Neutropenia in Patients With Acute Myeloid Leukemia
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Trial Identification
Brief Title: Shotgun Sequencing in Diagnosing Febrile Neutropenia in Patients With Acute Myeloid Leukemia
Official Title: Shotgun Sequencing for Etiologic Diagnosis of Febrile Neutropenia
Study ID: NCT02856204
Study Description
Brief Summary: This research trial studies the shotgun sequencing of blood samples in diagnosing febrile neutropenia in patients with acute myeloid leukemia. Studying samples of blood from patients with acute myeloid leukemia in the laboratory may help identify pathogens and accurately diagnose infections such as febrile neutropenia.
Detailed Description: PRIMARY OBJECTIVES: I. To test the hypothesis that shotgun metagenomics is not inferior to standard of care diagnostics in the detection of pathogens in patients with febrile neutropenia. SECONDARY OBJECTIVES: I. To establish a microbiological diagnosis with known or unknown pathogens in patients in whom standard care failed to yield a pathogenic diagnosis. OUTLINE: Patients undergo collection of blood samples before and during the episode of febrile neutropenia for up to 6 weeks.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Stanford University, School of Medicine, Palo Alto, California, United States
Contact Details
Name: Stanley Deresinski
Affiliation: Stanford University
Role: PRINCIPAL_INVESTIGATOR
Name: Steven Coutre
Affiliation: Stanford University
Role: PRINCIPAL_INVESTIGATOR
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