Spots Global Cancer Trial Database for HCT Versus CT in Elderly AML
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Trial Identification
Brief Title: HCT Versus CT in Elderly AML
Official Title: Randomized Phase III Study Comparing Conventional Chemotherapy to Low Dose Total Body Irradiation-Based Conditioning and HCT From Related and Unrelated Donors as Consolidation Therapy for Older Patients With AML in 1st Complete Remission
Study ID: NCT00766779
Conditions
Study Description
Brief Summary: A study comparing conventional chemotherapy to low dose total body irradiation-based conditioning and hematopoietic cell transplantation from related and unrelated donors as consolidation therapy for older Patients with AML in first Complete Remission.
Detailed Description: The majority of patients with acute myelogenous leukaemia (AML) enter complete remission following induction therapy, but relapse despite consolidation and maintenance therapy. In response, post-remission treatment has been progressively intensified and results improved either by high-dose post-remission therapy with autologous hematopoietic cell transplantation (HCT) or by allogeneic HCT, which has the highest curative potential for patients with AML. Given the toxicity of dose intensification and of allogeneic HCT, however, only younger patients profit from this treatment approach
Eligibility
Minimum Age: 60 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
The Alfred Hospital, Melbourne Victoria, , Australia
Hanusch Krankenhaus der Wiener Gebietskrankenkasse, Wien, , Austria
Medizinische Universität Wien, Wien, , Austria
ZNA Stuivenberg - Ziekenhuis Netwerk Antwerpen, Antwerpen, , Belgium
UZ Gasthuisberg Leuven, Leuven, , Belgium
Centre Hospitalier Sud Amiens, Amiens cedex 1, , France
Hopital Femme Enfant Hématologie, Caen Cedex 9, , France
Hôpital d'instruction des armées Percy, Clamart, , France
Centre hospitalier et universitaire (CHU) d´ Estaing, Clermont-Ferrand, , France
Centre hospitalier et universitaire (CHU) de Limoges, Limoges cedex, , France
Institut Paoli-Calmettes, Marseille cedex 9, , France
CHU de Nantes, Hôtel Dieu, Nantes cedex 01, , France
Centre Antoine Lacassagne, Nice cedex 2, , France
Centre hospitalier et universitaire (CHU) de Nice, Nice, , France
Hopital Saint Antoine, Paris 12ème, , France
CHU du Haut Lévêque, Pessac, , France
Centre Hospitalier (CH) Saint Quentin, Saint Quentin cedex, , France
University Aachen, Aachen, , Germany
II. Medizinische Klinik, Hämatologie/Internistische Onkologie, Augsburg, , Germany
Charité - Campus Benjamin Franklin, Berlin, , Germany
Klinikum Chemnitz gGmbH, Chemnitz, , Germany
Universitaetsklinikum Dresden, Dresden, , Germany
Klinik für Innere Medizin C, Greifswald, , Germany
University of Heidelberg, Heidelberg, , Germany
Friedrich-Schiller-Universität Jena, Jena, , Germany
University Hospital, Leipzig, , Germany
Universitätsklinikum Magdeburg AöR / Otto-von-Guericke Universität, Magdeburg, , Germany
University of Münster, Münster, , Germany
Klinikum Ernst von Bergmann gGmbH, Potsdam, , Germany
University Regensburg, Regensburg, , Germany
Universität Rostock, Rostock, , Germany
Robert-Bosch-Krankenhaus, Stuttgart, , Germany
Universität Tübingen, Tübingen, , Germany
Allogeneic Stem Cell Transplant Cente, Würzburg, , Germany
Academisch Ziekenhuis bij de Universiteit Amsterdam, Amsterdam, , Netherlands
VU University Medical Center Amsterdam, Amsterdam, , Netherlands
University Medical Centre Groningen, Groningen, , Netherlands
University Hospital Maastricht, Maastricht, , Netherlands
Erasmus MC-Daniel den Hoed Cancer Centre, Rotterdam, , Netherlands
University Medical Centre Utrecht, Utrecht, , Netherlands
Isala klinieken, Zwolle, , Netherlands
Kantonsspital Aarau, Aarau, , Switzerland
University Hospital, Basel, , Switzerland
Inselspital Bern, Bern, , Switzerland
Hopitaux Universitaires de Geneve, Geneve, , Switzerland
CHUV Lausanne, Lausanne, , Switzerland
Kantonsspital Luzern, Luzern 16, , Switzerland
University Hospital Zürich, Zürich, , Switzerland
Contact Details
Name: Dietger Niederwieser, Prof
Affiliation: EBMT and OSHO
Role: STUDY_CHAIR
Name: Bob Löwenberg, Prof
Affiliation: Stichting Hemato-Oncologie voor Volwassenen Nederland
Role: STUDY_CHAIR
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