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Brief Title: FT538 in Subjects With Advanced Hematologic Malignancies
Official Title: A Phase I, Open-Label, Multicenter Study of FT538 as Monotherapy in Relapsed/Refractory Acute Myelogenous Leukemia and in Combination With Monoclonal Antibodies in Relapsed/Refractory Multiple Myeloma
Study ID: NCT04614636
Brief Summary: This is a Phase I dose-finding study of FT538 as monotherapy in acute myeloid leukemia (AML) and in combination with monoclonal antibodies in multiple myeloma (MM). The study will consist of a dose-escalation stage and an expansion stage where participants will be enrolled into indication-specific cohorts.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Colorado Blood Cancer Institute, Denver, Colorado, United States
University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota, United States
Washington University, Saint Louis, Missouri, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Sarah Cannon Research Institute at Tennessee Oncology, Nashville, Tennessee, United States
St. David's South Austin Medical Center, Austin, Texas, United States
MD Anderson Cancer Center, Houston, Texas, United States
Texas Transplant Institute, San Antonio, Texas, United States
Name: Fate Trial Disclosure
Affiliation: Fate Therapeutics, Inc
Role: STUDY_DIRECTOR