Spots Global Cancer Trial Database for A Study to Evaluate Lanraplenib (LANRA) in Combination With Gilteritinib in Participants With FLT3-mutated Relapsed or Refractory Acute Myeloid Leukemia (AML)
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Trial Identification
Brief Title: A Study to Evaluate Lanraplenib (LANRA) in Combination With Gilteritinib in Participants With FLT3-mutated Relapsed or Refractory Acute Myeloid Leukemia (AML)
Official Title: A Phase 1b/2 Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of the Selective SYK Inhibitor Lanraplenib (LANRA) in Combination With the FLT3 Inhibitor Gilteritinib, in Patients With FLT3-mutated Relapsed or Refractory AML
Study ID: NCT05028751
Study Description
Brief Summary: The primary objective of this study is to evaluate the safety of lanraplenib (LANRA) in combination with the FMS-like tyrosine kinase 3 (FLT3) inhibitor gilteritinib, in participants with relapsed or refractory (R/R) FLT3-mutated acute myeloid leukemia (AML).
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of California Los Angeles (UCLA), Los Angeles, California, United States
The Blood and Marrow Transplant Group of Georgia, Atlanta, Georgia, United States
University of Chicago Medical Center, Chicago, Illinois, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Oregon Health and Science University, Portland, Oregon, United States
Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas, Texas, United States
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Froedtert Hospital, Milwaukee, Wisconsin, United States
Hospital Universitario 12 de Octubre, Madrid, Avenida De Córdoba Sin Número, Spain
Hospital Germans Trias i Pujol, Barcelona, Badalona, Spain
MD Anderson Cancer Center Madrid, Madrid, Calle De Arturo Soria, Spain
Hospital Universitari Vall d'Hebrón, Barcelona, , Spain
Institut Català d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet), Barcelona, , Spain
Hospital Clínic de Barcelona, Barcelona, , Spain
Hospital San Pedro de Alcantara, Cáceres, , Spain
Hospital Universitario Fundación Jiménez Díaz, Madrid, , Spain
Hospital Universitari i Politècnic La Fe, Valencia, , Spain
Contact Details
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