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Spots Global Cancer Trial Database for Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia

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Trial Identification

Brief Title: Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia

Official Title: Phase III Randomized Trial of Clofarabine as Induction and Post-Remission Therapy vs. Standard Daunorubicin &Amp; Cytarabine Induction and Intermediate Dose Cytarabine Post-Remission Therapy, Followed by Decitabine Maintenance vs. Observation in Newly-Diagnosed Acute Myeloid Leukemia in Older Adults (Age >/= 60 Years)

Study ID: NCT02085408

Study Description

Brief Summary: This randomized phase III trial studies clofarabine to see how well it works compared with daunorubicin hydrochloride and cytarabine when followed by decitabine or observation in treating older patients with newly diagnosed acute myeloid leukemia. Drugs used in chemotherapy, such as clofarabine, daunorubicin hydrochloride, cytarabine, and decitabine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. It is not yet known which chemotherapy regimen is more effective in treating acute myeloid leukemia.

Detailed Description: PRIMARY OBJECTIVES: I. To evaluate the effect of clofarabine induction and consolidation therapy on overall survival in comparison with standard therapy (daunorubicin \[daunorubicin hydrochloride\] \& cytarabine) in newly-diagnosed acute myeloid leukemia (AML) patients age \>= 60 years. SECONDARY OBJECTIVES: I. To evaluate complete remission (CR) rates, duration of remission, and toxicity/treatment-related mortality of clofarabine in comparison with standard therapy (daunorubicin \& cytarabine) in newly-diagnosed AML patients age \>= 60 years. II. To evaluate the feasibility of consolidation with reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation from human leukocyte antigen (HLA)-identical donors in patients who achieve a response to induction therapy, including the incidence of successful engraftment, acute and chronic graft-versus-host disease, transplant-related mortality, and its impact on overall survival in comparison to patients receiving chemotherapy. III. To evaluate the duration of remission and disease-free survival of patients in complete remission following completion of consolidation therapy who are subsequently randomized to receive scheduled low-dose decitabine maintenance in comparison with observation. IV. To perform expression and methylation profiling on all patients receiving decitabine and to correlate their integrated epigenetic signatures with response to decitabine. V. To examine the epigenetic profiles of remission marrow in patients randomized to observation vs. decitabine to determine whether epigenetic signature of apparently morphologically normal bone marrow is predictive of relapse or response to decitabine maintenance. VI. To explore the possible association of response to clofarabine with ABC-transporter P-glycoprotein (Pgp). VII. To assess the intensity of expression of CXC chemokine receptor type 4 (CXCR4) on diagnostic leukemia cells and to correlate this parameter with other established prognostic factors. VIII. To assess the entire spectrum of somatic mutations and affected pathways at diagnosis of AML and elucidate the association between gene mutation and outcome. IX. To examine the impact of smoking, obesity, regular acetaminophen use, regular aspirin use, benzene exposure, living in a rural/farm environment and some other underlying exposures and lifestyle factors associated with AML development on overall survival (OS). X. To investigate potential correlative results between array comparative genomic hybridization (CGH) findings and acute myeloid leukemia patient characteristics. TERTIARY OBJECTIVES: I. To compare health-related quality of life (QOL) (physical, functional, leukemia-specific well-being) and fatigue in elderly AML patients receiving standard induction therapy with those receiving clofarabine. II. To measure the change in health-related QOL that occurs over time (within treatment groups). III. To comprehensively assess patient function at the time of study enrollment. IV. To determine if components of a comprehensive geriatric assessment or QOL scales predict ability to complete AML treatment. V. To describe the impact of transplant on QOL in AML patients above age 60. OUTLINE: INDUCTION THERAPY: Patients are randomized to 1 of 2 treatment arms. ARM A (STANDARD THERAPY): Patients receive daunorubicin hydrochloride at 60 mg/m\^2 intravenously (IV) over 10-15 minutes on days 1-3 and cytarabine at 100 mg/m\^2 IV continuously on days 1-7. Patients with residual disease or those who do not achieve an aplastic bone marrow on day 12-14 (i.e., \< 5% blasts and \< 20% cellularity or markedly/moderately hypocellular) may receive a second course of induction therapy beginning no sooner than day 14. ARM B: Patients receive clofarabine at 30 mg/m\^2 IV over 1 hour on days 1-5. Patients with residual disease or those who do not achieve an aplastic bone marrow on day 12-14 (i.e., \< 5% blasts and \< 20% cellularity or markedly/moderately hypocellular) may receive a second course of induction therapy beginning no sooner than day 21 and no later than day 56. Patients who achieve a complete remission (CR) or CR with incomplete marrow recovery (CRi) after induction therapy proceed to consolidation therapy (Arms C and D). Patients who are 60-69 years of age who achieve a "morphologic leukemia-free state" after induction therapy and who have an HLA-identical donor proceed to allogeneic stem cell transplantation. CONSOLIDATION THERAPY: Beginning within 60 days after documentation of CR or CRi, patients receive consolidation therapy in the same arm they were randomized to for induction therapy. ARM C (STANDARD THERAPY): Patients receive cytarabine at 1500 mg/m\^2 IV over 1 hour once or twice daily on days 1-6. Treatment repeats every 4-6 weeks for 2 courses. ARM D: Patients receive clofarabine at 20 mg/m\^2 IV over 1 hour on days 1-5. Treatment repeats every 4-6 weeks for 2 courses. Patients who remain in CR after completion of consolidation therapy are randomized to one of the two maintenance therapy arms (Arms E and F). MAINTENANCE THERAPY: Beginning within 60 days after completion of consolidation therapy, patients receive maintenance therapy and are randomized to 1 of 2 arms. Patients not eligible for randomization to decitabine maintenance after recovery from consolidation will be followed according to Arm E. ARM E: Patients undergo observation monthly for 12 months. ARM F: Patients receive decitabine at 20 mg/m\^2 IV over 1 hour on days 1-3. Treatment repeats every 4 weeks for 12 months the absence of unacceptable toxicity. ALLOGENEIC STEM CELL TRANSPLANTATION WITH REDUCED-INTENSITY CONDITIONING REGIMEN (Arm G): Patients begin reduced-intensity conditioning 30-90 days after the initiation of induction therapy. CONDITIONING REGIMEN: Patients receive fludarabine phosphate at 30 mg/m\^2 IV over 30 minutes on days -7 to -3, busulfan at 0.8 mg/kg IV over 2 hours every 6 hours on days -4 and -3 (for a total of 8 doses), and anti-thymocyte globulin at 2.5 mg/kg/day IV over 4-6 hours on days -4 to -2. TRANSPLANTATION: Patients undergo allogeneic peripheral blood stem cell transplantation on day 0. After completion of study treatment, patients are followed up every 3 months for 4 years, every 6 months for 1 year, and then annually thereafter.

Eligibility

Minimum Age: 60 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

University of Alabama at Birmingham, Birmingham, Alabama, United States

Mayo Clinic in Arizona, Scottsdale, Arizona, United States

Arizona Cancer Center at University Medical Center North, Tucson, Arizona, United States

University of Arizona Health Sciences Center, Tucson, Arizona, United States

The Medical Center of Aurora, Aurora, Colorado, United States

Boulder Community Hospital, Boulder, Colorado, United States

Penrose-Saint Francis Healthcare, Colorado Springs, Colorado, United States

Saint Anthony Central Hospital, Denver, Colorado, United States

Porter Adventist Hospital, Denver, Colorado, United States

Exempla Saint Joseph Hospital, Denver, Colorado, United States

Presbyterian - Saint Lukes Medical Center - Health One, Denver, Colorado, United States

Rose Medical Center, Denver, Colorado, United States

Colorado Cancer Research Program CCOP, Denver, Colorado, United States

Swedish Medical Center, Englewood, Colorado, United States

North Colorado Medical Center, Greeley, Colorado, United States

Littleton Adventist Hospital, Littleton, Colorado, United States

Sky Ridge Medical Center, Lone Tree, Colorado, United States

Longmont United Hospital, Longmont, Colorado, United States

McKee Medical Center, Loveland, Colorado, United States

Parker Adventist Hospital, Parker, Colorado, United States

Saint Mary Corwin Medical Center, Pueblo, Colorado, United States

North Suburban Medical Center, Thornton, Colorado, United States

Exempla Lutheran Medical Center, Wheat Ridge, Colorado, United States

Saint Francis Hospital and Medical Center, Hartford, Connecticut, United States

The Hospital of Central Connecticut, New Britain, Connecticut, United States

Beebe Medical Center, Lewes, Delaware, United States

Christiana Care Health System-Christiana Hospital, Newark, Delaware, United States

University of Florida, Gainesville, Florida, United States

Mayo Clinic in Florida, Jacksonville, Florida, United States

Florida Hospital, Orlando, Florida, United States

Piedmont Hospital, Atlanta, Georgia, United States

Atlanta Regional CCOP, Atlanta, Georgia, United States

Northside Hospital, Atlanta, Georgia, United States

Saint Joseph's Hospital of Atlanta, Atlanta, Georgia, United States

Georgia Regents University, Augusta, Georgia, United States

Well Star Cobb Hospital, Austell, Georgia, United States

John B Amos Cancer Center, Columbus, Georgia, United States

Dekalb Medical Center, Decatur, Georgia, United States

Piedmont Fayette Hospital, Fayetteville, Georgia, United States

Gwinnett Medical Center, Lawrenceville, Georgia, United States

Wellstar Kennestone Hospital, Marietta, Georgia, United States

Southern Regional Medical Center, Riverdale, Georgia, United States

Harbin Clinic Medical Oncology and Clinical Research, Rome, Georgia, United States

Kapiolani Medical Center at Pali Momi, 'Aiea, Hawaii, United States

Oncare Hawaii Inc - Kapiolani Medical Center at Pali Momi, 'Aiea, Hawaii, United States

Oncare Hawaii Inc-POB II, Honolulu, Hawaii, United States

Queen's Medical Center, Honolulu, Hawaii, United States

Straub Clinic and Hospital, Honolulu, Hawaii, United States

University of Hawaii, Honolulu, Hawaii, United States

OnCare Hawaii-Liliha, Honolulu, Hawaii, United States

Kuakini Medical Center, Honolulu, Hawaii, United States

Oncare Hawaii Inc-Kuakini, Honolulu, Hawaii, United States

Kapiolani Medical Center for Women and Children, Honolulu, Hawaii, United States

Castle Medical Center, Kailua, Hawaii, United States

Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue, Hawaii, United States

Saint Alphonsus Regional Medical Center, Boise, Idaho, United States

Saint Anthony's Health, Alton, Illinois, United States

Illinois CancerCare-Bloomington, Bloomington, Illinois, United States

Saint Joseph Medical Center, Bloomington, Illinois, United States

Graham Hospital Association, Canton, Illinois, United States

Illinois CancerCare-Canton, Canton, Illinois, United States

Illinois CancerCare-Carthage, Carthage, Illinois, United States

Memorial Hospital, Carthage, Illinois, United States

Mount Sinai Hospital Medical Center, Chicago, Illinois, United States

Hematology and Oncology Associates, Chicago, Illinois, United States

Northwestern University, Chicago, Illinois, United States

University of Illinois, Chicago, Illinois, United States

Decatur Memorial Hospital, Decatur, Illinois, United States

Eureka Hospital, Eureka, Illinois, United States

Illinois CancerCare-Eureka, Eureka, Illinois, United States

Illinois CancerCare Galesburg, Galesburg, Illinois, United States

Western Illinois Cancer Treatment Center, Galesburg, Illinois, United States

Illinois CancerCare-Havana, Havana, Illinois, United States

Mason District Hospital, Havana, Illinois, United States

Hematology Oncology Associates of Illinois-Highland Park, Highland Park, Illinois, United States

Hinsdale Hematology Oncology Associates Incorporated, Hinsdale, Illinois, United States

Presence Saint Mary's Hospital, Kankakee, Illinois, United States

Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois, United States

North Shore Hematology Oncology, Libertyville, Illinois, United States

Illinois CancerCare-Macomb, Macomb, Illinois, United States

Mcdonough District Hospital, Macomb, Illinois, United States

Loyola University Medical Center, Maywood, Illinois, United States

Holy Family Medical Center, Monmouth, Illinois, United States

Illinois CancerCare-Monmouth, Monmouth, Illinois, United States

Illinois Cancer Specialists-Niles, Niles, Illinois, United States

Bromenn Regional Medical Center, Normal, Illinois, United States

Community Cancer Center Foundation, Normal, Illinois, United States

Illinois CancerCare-Community Cancer Center, Normal, Illinois, United States

Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois, United States

Ottawa Regional Hospital and Healthcare Center, Ottawa, Illinois, United States

Pekin Cancer Treatment Center, Pekin, Illinois, United States

Illinois CancerCare-Pekin, Pekin, Illinois, United States

Methodist Medical Center of Illinois, Peoria, Illinois, United States

Proctor Hospital, Peoria, Illinois, United States

Illinois CancerCare-Peoria, Peoria, Illinois, United States

Illinois Oncology Research Association CCOP, Peoria, Illinois, United States

OSF Saint Francis Medical Center, Peoria, Illinois, United States

Illinois CancerCare-Peru, Peru, Illinois, United States

Illinois Valley Hospital, Peru, Illinois, United States

Illinois CancerCare-Princeton, Princeton, Illinois, United States

Perry Memorial Hospital, Princeton, Illinois, United States

Swedish American Hospital, Rockford, Illinois, United States

Hematology Oncology Associates of Illinois - Skokie, Skokie, Illinois, United States

Illinois CancerCare-Spring Valley, Spring Valley, Illinois, United States

Memorial Medical Center, Springfield, Illinois, United States

Saint Francis Hospital and Health Centers, Beech Grove, Indiana, United States

Fort Wayne Medical Oncology and Hematology Inc - State Boulevard, Fort Wayne, Indiana, United States

Franciscan St. Francis Health, Indianapolis, Indiana, United States

Reid Hospital and Health Care Services, Richmond, Indiana, United States

McFarland Clinic, Ames, Iowa, United States

Siouxland Hematology Oncology Associates, Sioux City, Iowa, United States

Mercy Medical Center-Sioux City, Sioux City, Iowa, United States

Saint Luke's Regional Medical Center, Sioux City, Iowa, United States

University of Kentucky, Lexington, Kentucky, United States

Norton Health Care Pavilion - Downtown, Louisville, Kentucky, United States

Ochsner Clinic Foundation-Baton Rouge, Baton Rouge, Louisiana, United States

Ochsner Baptist Medical Center, New Orleans, Louisiana, United States

Ochsner Clinic Foundation, New Orleans, Louisiana, United States

Harold Alfond Center for Cancer Care, Augusta, Maine, United States

Eastern Maine Medical Center, Bangor, Maine, United States

Johns Hopkins University, Baltimore, Maryland, United States

Walter Reed National Military Medical Center, Bethesda, Maryland, United States

Union Hospital of Cecil County, Elkton, Maryland, United States

Tufts Medical Center, Boston, Massachusetts, United States

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Caritas Saint Elizabeth's Medical Center, Brighton, Massachusetts, United States

Baystate Medical Center, Springfield, Massachusetts, United States

Saint Joseph Mercy Hospital, Ann Arbor, Michigan, United States

Michigan Cancer Research Consortium Community Clinical Oncology Program, Ann Arbor, Michigan, United States

Bronson Battle Creek, Battle Creek, Michigan, United States

Mecosta County Medical Center, Big Rapids, Michigan, United States

Oakwood Hospital, Dearborn, Michigan, United States

Wayne State University, Detroit, Michigan, United States

Saint John Hospital and Medical Center, Detroit, Michigan, United States

Hurley Medical Center, Flint, Michigan, United States

Genesys Hurley Cancer Institute, Flint, Michigan, United States

Genesys Regional Medical Center-West Flint Campus, Flint, Michigan, United States

Genesys Regional Medical Center, Grand Blanc, Michigan, United States

Grand Rapids Clinical Oncology Program, Grand Rapids, Michigan, United States

Saint Mary's Health Care, Grand Rapids, Michigan, United States

Spectrum Health at Butterworth Campus, Grand Rapids, Michigan, United States

Allegiance Health, Jackson, Michigan, United States

Borgess Medical Center, Kalamazoo, Michigan, United States

Bronson Methodist Hospital, Kalamazoo, Michigan, United States

West Michigan Cancer Center, Kalamazoo, Michigan, United States

Sparrow Hospital, Lansing, Michigan, United States

Saint Mary Mercy Hospital, Livonia, Michigan, United States

Mercy Health Partners-Mercy Campus, Muskegon, Michigan, United States

Saint Joseph Mercy Oakland, Pontiac, Michigan, United States

Saint Joseph Mercy Port Huron, Port Huron, Michigan, United States

Spectrum Health Reed City Hospital, Reed City, Michigan, United States

Saint Mary's of Michigan, Saginaw, Michigan, United States

Providence Hospital, Southfield, Michigan, United States

Munson Medical Center, Traverse City, Michigan, United States

Saint John Macomb-Oakland Hospital, Warren, Michigan, United States

Sanford Clinic North-Bemidgi, Bemidji, Minnesota, United States

Essentia Health Saint Joseph's Medical Center, Brainerd, Minnesota, United States

Essentia Health Duluth Clinic CCOP, Duluth, Minnesota, United States

Essentia Health Saint Mary's Medical Center, Duluth, Minnesota, United States

Miller-Dwan Hospital, Duluth, Minnesota, United States

Lake Region Healthcare Corporation-Cancer Care, Fergus Falls, Minnesota, United States

Mayo Clinic, Rochester, Minnesota, United States

University of Mississippi Medical Center, Jackson, Mississippi, United States

Saint Francis Medical Center, Cape Girardeau, Missouri, United States

Saint Louis Cancer and Breast Institute-South City, Saint Louis, Missouri, United States

Saint Louis University Hospital, Saint Louis, Missouri, United States

Washington University School of Medicine, Saint Louis, Missouri, United States

Saint John's Mercy Medical Center, Saint Louis, Missouri, United States

Saint Louis-Cape Girardeau CCOP, Saint Louis, Missouri, United States

Montana Cancer Consortium CCOP, Billings, Montana, United States

Saint Vincent Healthcare, Billings, Montana, United States

Hematology-Oncology Centers of the Northern Rockies PC, Billings, Montana, United States

Billings Clinic, Billings, Montana, United States

Bozeman Deaconess Cancer Center, Bozeman, Montana, United States

Bozeman Deaconess Hospital, Bozeman, Montana, United States

Saint James Community Hospital and Cancer Treatment Center, Butte, Montana, United States

Benefis Healthcare- Sletten Cancer Institute, Great Falls, Montana, United States

Great Falls Clinic, Great Falls, Montana, United States

Northern Montana Hospital, Havre, Montana, United States

Saint Peter's Community Hospital, Helena, Montana, United States

Glacier Oncology PLLC, Kalispell, Montana, United States

Kalispell Medical Oncology, Kalispell, Montana, United States

Kalispell Regional Medical Center, Kalispell, Montana, United States

Montana Cancer Specialists, Missoula, Montana, United States

Saint Patrick Hospital - Community Hospital, Missoula, Montana, United States

Nevada Cancer Research Foundation CCOP, Las Vegas, Nevada, United States

Cooper Hospital University Medical Center, Camden, New Jersey, United States

Winthrop University Hospital, Mineola, New York, United States

Memorial Sloan Kettering Cancer Center, New York, New York, United States

University of Rochester, Rochester, New York, United States

Park Ridge Hospital Breast Health Center, Hendersonville, North Carolina, United States

Kinston Medical Specialists PA, Kinston, North Carolina, United States

Roger Maris Cancer Center, Fargo, North Dakota, United States

Sanford Clinic North-Fargo, Fargo, North Dakota, United States

Sanford Medical Center-Fargo, Fargo, North Dakota, United States

Summa Akron City Hospital, Akron, Ohio, United States

Akron General Medical Center, Akron, Ohio, United States

Summa Barberton Hospital, Barberton, Ohio, United States

Aultman Health Foundation, Canton, Ohio, United States

The Jewish Hospital, Cincinnati, Ohio, United States

Case Western Reserve University, Cleveland, Ohio, United States

Grandview Hospital, Dayton, Ohio, United States

Good Samaritan Hospital - Dayton, Dayton, Ohio, United States

Miami Valley Hospital, Dayton, Ohio, United States

Samaritan North Health Center, Dayton, Ohio, United States

Dayton CCOP, Dayton, Ohio, United States

Blanchard Valley Hospital, Findlay, Ohio, United States

Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio, United States

Wayne Hospital, Greenville, Ohio, United States

Kettering Medical Center, Kettering, Ohio, United States

Saint Rita's Medical Center, Lima, Ohio, United States

Upper Valley Medical Center, Troy, Ohio, United States

Clinton Memorial Hospital, Wilmington, Ohio, United States

Greene Memorial Hospital, Xenia, Ohio, United States

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States

Clackamas Radiation Oncology Center, Clackamas, Oregon, United States

Providence Milwaukie Hospital, Milwaukie, Oregon, United States

Providence Newberg Medical Center, Newberg, Oregon, United States

Providence Willamette Falls Medical Center, Oregon City, Oregon, United States

Providence Portland Medical Center, Portland, Oregon, United States

Columbia River Oncology Program, Portland, Oregon, United States

Providence Saint Vincent Medical Center, Portland, Oregon, United States

Lehigh Valley Hospital, Allentown, Pennsylvania, United States

Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania, United States

Geisinger Medical Center, Danville, Pennsylvania, United States

Geisinger Medical Center-Cancer Center Hazelton, Hazleton, Pennsylvania, United States

Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, United States

Lewistown Hospital, Lewistown, Pennsylvania, United States

Abramson Cancer Center of The University of Pennsylvania, Philadelphia, Pennsylvania, United States

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States

Geisinger Medical Group, State College, Pennsylvania, United States

Mount Nittany Medical Center, State College, Pennsylvania, United States

Geisinger Wyoming Valley, Wilkes-Barre, Pennsylvania, United States

York Hospital, York, Pennsylvania, United States

AnMed Health Cancer Center, Anderson, South Carolina, United States

Saint Francis Hospital, Greenville, South Carolina, United States

Carolina Blood and Cancer Care Associates PA-Lancaster, Lancaster, South Carolina, United States

Carolina Blood and Cancer Care Associates PA, Rock Hill, South Carolina, United States

Spartanburg Regional Medical Center, Spartanburg, South Carolina, United States

Upstate Carolina CCOP, Spartanburg, South Carolina, United States

Sanford Cancer Center-Oncology Clinic, Sioux Falls, South Dakota, United States

Medical X-Ray Center, Sioux Falls, South Dakota, United States

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota, United States

Erlanger Medical Center, Chattanooga, Tennessee, United States

Jackson-Madison County General Hospital, Jackson, Tennessee, United States

Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States

PeaceHealth Southwest Medical Center, Vancouver, Washington, United States

Northwest Cancer Specialists, Vancouver, Washington, United States

West Virginia University Charleston, Charleston, West Virginia, United States

West Virginia University, Morgantown, West Virginia, United States

Green Bay Oncology at Saint Vincent Hospital, Green Bay, Wisconsin, United States

Saint Vincent Hospital, Green Bay, Wisconsin, United States

Green Bay Oncology Limited at Saint Mary's Hospital, Green Bay, Wisconsin, United States

Saint Mary's Hospital, Green Bay, Wisconsin, United States

Gundersen Lutheran, La Crosse, Wisconsin, United States

University of Wisconsin Hospital and Clinics, Madison, Wisconsin, United States

Holy Family Memorial Hospital, Manitowoc, Wisconsin, United States

Bay Area Medical Center, Marinette, Wisconsin, United States

Froedtert and the Medical College of Wisconsin, Milwaukee, Wisconsin, United States

D N Greenwald Center, Mukwonago, Wisconsin, United States

Oconomowoc Memorial Hospital-ProHealth Care Inc, Oconomowoc, Wisconsin, United States

Saint Nicholas Hospital, Sheboygan, Wisconsin, United States

Waukesha Memorial Hospital - ProHealth Care, Waukesha, Wisconsin, United States

Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin, United States

Rocky Mountain Oncology, Casper, Wyoming, United States

Welch Cancer Center, Sheridan, Wyoming, United States

Mayo Clinic Methodist Hospital, Nagpur, , India

Rambam Medical Center, Haifa, , Israel

Shaare Zedek Medical Center, Jerusalem, , Israel

Contact Details

Name: James Foran

Affiliation: Eastern Cooperative Oncology Group

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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