Spots Global Cancer Trial Database for Akt Inhibitor MK2206 in Treating Patients With Advanced Gastric or Gastroesophageal Junction Cancer
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Trial Identification
Brief Title: Akt Inhibitor MK2206 in Treating Patients With Advanced Gastric or Gastroesophageal Junction Cancer
Official Title: A Phase II Study of MK-2206 (NSC-749607) as Second Line Therapy for Advanced Gastric and Gastroesophageal Junction Cancer
Study ID: NCT01260701
Interventions
Study Description
Brief Summary: This phase II clinical trial studies how well Akt inhibitor MK2206 works in treating patients with advanced gastric or gastroesophageal junction cancer. Akt inhibitor MK2206 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Detailed Description: PRIMARY OBJECTIVES: I. To estimate the overall survival (OS) for patients with advanced gastric and gastroesophageal junction (GEJ) adenocarcinoma treated with MK-2206 (Akt inhibitor MK2206). SECONDARY OBJECTIVES: I. To estimate the progression free survival (PFS) in this patient population. II. To estimate the response rate (confirmed and unconfirmed complete response \[CR\] and partial response \[PR\] by Response Evaluation Criteria In Solid Tumors \[RECIST\] 1.1) in this patient population. III. To assess the frequency and severity of toxicity associated with this regimen. OUTLINE (CLOSED TO ACCRUAL 05/01/13): Patients receive Akt inhibitor MK2206 orally (PO) every other day on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. After completion of study therapy, patients are followed up every 3 months for 2 years.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Providence Hospital, Mobile, Alabama, United States
Fairbanks Memorial Hospital, Fairbanks, Alaska, United States
The University of Arizona Cancer Center-Orange Grove Campus, Tucson, Arizona, United States
The University of Arizona Cancer Center-North Campus, Tucson, Arizona, United States
The University of Arizona Medical Center-University Campus, Tucson, Arizona, United States
Fowler Family Center for Cancer Care, Jonesboro, Arkansas, United States
NEA Baptist Memorial Hospital, Jonesboro, Arkansas, United States
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
USC / Norris Comprehensive Cancer Center, Los Angeles, California, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California, United States
Poudre Valley Hospital, Fort Collins, Colorado, United States
Front Range Cancer Specialists, Fort Collins, Colorado, United States
Saint Francis Hospital and Medical Center, Hartford, Connecticut, United States
UF Cancer Center at Orlando Health, Orlando, Florida, United States
Memorial University Medical Center, Savannah, Georgia, United States
Oncare Hawaii Inc-Pali Momi, Aiea, Hawaii, United States
Pali Momi Medical Center, Aiea, Hawaii, United States
Oncare Hawaii Inc-POB II, Honolulu, Hawaii, United States
Queen's Medical Center, Honolulu, Hawaii, United States
Straub Clinic and Hospital, Honolulu, Hawaii, United States
University of Hawaii Cancer Center, Honolulu, Hawaii, United States
OnCare Hawaii-Liliha, Honolulu, Hawaii, United States
Kuakini Medical Center, Honolulu, Hawaii, United States
Oncare Hawaii Inc-Kuakini, Honolulu, Hawaii, United States
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii, United States
Castle Medical Center, Kailua, Hawaii, United States
Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue, Hawaii, United States
Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho, United States
Cadence Cancer Center at Delnor, Geneva, Illinois, United States
Loyola University Medical Center, Maywood, Illinois, United States
Cadence Cancer Center in Warrenville, Warrenville, Illinois, United States
Franciscan St. Francis Health-Beech Grove, Beech Grove, Indiana, United States
Franciscan Saint Francis Health-Indianapolis, Indianapolis, Indiana, United States
Reid Hospital and Health Care Services, Richmond, Indiana, United States
Cancer Center of Kansas - Chanute, Chanute, Kansas, United States
Cancer Center of Kansas - Dodge City, Dodge City, Kansas, United States
Cancer Center of Kansas - Fort Scott, Fort Scott, Kansas, United States
Saint Rose Ambulatory and Surgery Center, Great Bend, Kansas, United States
Hays Medical Center, Hays, Kansas, United States
Hutchinson Regional Medical Center, Hutchinson, Kansas, United States
Cancer Center of Kansas-Independence, Independence, Kansas, United States
The University of Kansas Cancer Center-West, Kansas City, Kansas, United States
University of Kansas Cancer Center, Kansas City, Kansas, United States
Cancer Center of Kansas-Kingman, Kingman, Kansas, United States
Lawrence Memorial Hospital, Lawrence, Kansas, United States
Cancer Center of Kansas-Liberal, Liberal, Kansas, United States
Cancer Center of Kansas - Newton, Newton, Kansas, United States
Kansas City Cancer Centers-Southwest, Overland Park, Kansas, United States
Cancer Center of Kansas - Parsons, Parsons, Kansas, United States
Via Christi Hospital-Pittsburg, Pittsburg, Kansas, United States
Cancer Center of Kansas - Pratt, Pratt, Kansas, United States
Cancer Center of Kansas - Salina, Salina, Kansas, United States
Salina Regional Health Center, Salina, Kansas, United States
Kansas City Cancer Center-Shawnee Mission, Shawnee Mission, Kansas, United States
Saint Francis Hospital and Medical Center - Topeka, Topeka, Kansas, United States
Cancer Center of Kansas - Wellington, Wellington, Kansas, United States
Associates In Womens Health, Wichita, Kansas, United States
Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita, Kansas, United States
Cancer Center of Kansas - Main Office, Wichita, Kansas, United States
Via Christi Regional Medical Center, Wichita, Kansas, United States
Wichita CCOP, Wichita, Kansas, United States
Cancer Center of Kansas - Winfield, Winfield, Kansas, United States
Sinai Hospital of Baltimore, Baltimore, Maryland, United States
Saint Joseph Mercy Hospital, Ann Arbor, Michigan, United States
Michigan Cancer Research Consortium CCOP, Ann Arbor, Michigan, United States
Bronson Battle Creek, Battle Creek, Michigan, United States
Spectrum Health Big Rapids Hospital, Big Rapids, Michigan, United States
Oakwood Hospital and Medical Center, Dearborn, Michigan, United States
Saint John Hospital and Medical Center, Detroit, Michigan, United States
Hurley Medical Center, Flint, Michigan, United States
Genesys Hurley Cancer Institute, Flint, Michigan, United States
Genesys Regional Medical Center-West Flint Campus, Flint, Michigan, United States
Grand Rapids Clinical Oncology Program, Grand Rapids, Michigan, United States
Mercy Health Saint Mary's, Grand Rapids, Michigan, United States
Spectrum Health at Butterworth Campus, Grand Rapids, Michigan, United States
Allegiance Health, Jackson, Michigan, United States
Sparrow Hospital, Lansing, Michigan, United States
Saint Mary Mercy Hospital, Livonia, Michigan, United States
Mercy Health Mercy Campus, Muskegon, Michigan, United States
Saint Joseph Mercy Oakland, Pontiac, Michigan, United States
Saint Joseph Mercy Port Huron, Port Huron, Michigan, United States
Spectrum Health Reed City Hospital, Reed City, Michigan, United States
Saint Mary's of Michigan, Saginaw, Michigan, United States
Munson Medical Center, Traverse City, Michigan, United States
Saint John Macomb-Oakland Hospital, Warren, Michigan, United States
Metro Health Hospital, Wyoming, Michigan, United States
Truman Medical Center, Kansas City, Missouri, United States
Kansas City Cancer Center - South, Kansas City, Missouri, United States
Kansas City Cancer Centers - North, Kansas City, Missouri, United States
Kansas City Cancer Center-Lee's Summit, Lee's Summit, Missouri, United States
Saint John's Clinic-Rolla-Cancer and Hematology, Rolla, Missouri, United States
Saint Louis University Hospital, Saint Louis, Missouri, United States
Cancer Research for the Ozarks NCORP, Springfield, Missouri, United States
Mercy Hospital Springfield, Springfield, Missouri, United States
CoxHealth South Hospital, Springfield, Missouri, United States
Montana Cancer Consortium NCORP, Billings, Montana, United States
Saint Vincent Healthcare, Billings, Montana, United States
Frontier Cancer Center and Blood Institute-Billings, Billings, Montana, United States
Billings Clinic Cancer Center, Billings, Montana, United States
Bozeman Deaconess Cancer Center, Bozeman, Montana, United States
Bozeman Deaconess Hospital, Bozeman, Montana, United States
Saint James Community Hospital and Cancer Treatment Center, Butte, Montana, United States
Benefis Healthcare- Sletten Cancer Institute, Great Falls, Montana, United States
Great Falls Clinic, Great Falls, Montana, United States
Saint Peter's Community Hospital, Helena, Montana, United States
Glacier Oncology PLLC, Kalispell, Montana, United States
Kalispell Regional Medical Center, Kalispell, Montana, United States
Montana Cancer Specialists, Missoula, Montana, United States
Saint Patrick Hospital - Community Hospital, Missoula, Montana, United States
Winthrop University Hospital, Mineola, New York, United States
Interlakes Foundation Inc-Rochester, Rochester, New York, United States
University of Rochester, Rochester, New York, United States
Randolph Hospital, Asheboro, North Carolina, United States
Novant Health Presbyterian Medical Center, Charlotte, North Carolina, United States
Wayne Memorial Hospital, Goldsboro, North Carolina, United States
Cone Health Cancer Center, Greensboro, North Carolina, United States
Iredell Memorial Hospital, Statesville, North Carolina, United States
Southeast Cancer Control Consortium CCOP, Winston-Salem, North Carolina, United States
Akron General Medical Center, Akron, Ohio, United States
Mary Rutan Hospital, Bellefontaine, Ohio, United States
Adena Regional Medical Center, Chillicothe, Ohio, United States
Good Samaritan Hospital - Cincinnati, Cincinnati, Ohio, United States
University of Cincinnati, Cincinnati, Ohio, United States
Riverside Methodist Hospital, Columbus, Ohio, United States
Columbus CCOP, Columbus, Ohio, United States
Grant Medical Center, Columbus, Ohio, United States
Mount Carmel Health Center West, Columbus, Ohio, United States
Doctors Hospital, Columbus, Ohio, United States
Grandview Hospital, Dayton, Ohio, United States
Good Samaritan Hospital - Dayton, Dayton, Ohio, United States
Miami Valley Hospital, Dayton, Ohio, United States
Samaritan North Health Center, Dayton, Ohio, United States
Dayton CCOP, Dayton, Ohio, United States
Grady Memorial Hospital, Delaware, Ohio, United States
Blanchard Valley Hospital, Findlay, Ohio, United States
Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio, United States
Wayne Hospital, Greenville, Ohio, United States
Kettering Medical Center, Kettering, Ohio, United States
Fairfield Medical Center, Lancaster, Ohio, United States
Marietta Memorial Hospital, Marietta, Ohio, United States
Knox Community Hospital, Mount Vernon, Ohio, United States
Licking Memorial Hospital, Newark, Ohio, United States
Southern Ohio Medical Center, Portsmouth, Ohio, United States
Springfield Regional Medical Center, Springfield, Ohio, United States
Upper Valley Medical Center, Troy, Ohio, United States
Saint Ann's Hospital, Westerville, Ohio, United States
Clinton Memorial Hospital, Wilmington, Ohio, United States
Greene Memorial Hospital, Xenia, Ohio, United States
Genesis HealthCare System, Zanesville, Ohio, United States
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
Oregon Health and Science University, Portland, Oregon, United States
McLeod Regional Medical Center, Florence, South Carolina, United States
University of Tennessee - Knoxville, Knoxville, Tennessee, United States
Baylor College of Medicine, Houston, Texas, United States
Baylor Saint Luke's Medical Center, Houston, Texas, United States
Ben Taub General Hospital, Houston, Texas, United States
Michael E DeBakey VA Medical Center, Houston, Texas, United States
Danville Regional Medical Center, Danville, Virginia, United States
Memorial Hospital Of Martinsville, Martinsville, Virginia, United States
Cancer Care Center at Island Hospital, Anacortes, Washington, United States
PeaceHealth Saint Joseph Medical Center, Bellingham, Washington, United States
Harrison HealthPartners Hematology and Oncology-Bremerton, Bremerton, Washington, United States
Highline Medical Center-Main Campus, Burien, Washington, United States
Swedish Cancer Institute-Issaquah, Issaquah, Washington, United States
Kadlec Clinic Hematology and Oncology, Kennewick, Washington, United States
EvergreenHealth Medical Center, Kirkland, Washington, United States
Seattle Cancer Care Alliance at EvergreenHealth, Kirkland, Washington, United States
Skagit Valley Hospital, Mount Vernon, Washington, United States
Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo, Washington, United States
Virginia Mason CCOP, Seattle, Washington, United States
Harborview Medical Center, Seattle, Washington, United States
Minor and James Medical PLLC, Seattle, Washington, United States
Pacific Medical Center-First Hill, Seattle, Washington, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
Group Health Cooperative of Puget Sound Oncology Consortium, Seattle, Washington, United States
Group Health Cooperative-Seattle, Seattle, Washington, United States
Swedish Medical Center-First Hill, Seattle, Washington, United States
The Polyclinic, Seattle, Washington, United States
University of Washington Medical Center, Seattle, Washington, United States
United General Hospital, Sedro-Woolley, Washington, United States
Cancer Care Northwest - Spokane South, Spokane, Washington, United States
Evergreen Hematology and Oncology PS, Spokane, Washington, United States
Rockwood Clinic, Spokane, Washington, United States
Wenatchee Valley Hospital and Clinics, Wenatchee, Washington, United States
Rocky Mountain Oncology, Casper, Wyoming, United States
Welch Cancer Center, Sheridan, Wyoming, United States
BCCA-Vancouver Cancer Centre, Vancouver, British Columbia, Canada
Contact Details
Name: Ramesh Ramanathan
Affiliation: SWOG Cancer Research Network
Role: PRINCIPAL_INVESTIGATOR
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