Spots Global Cancer Trial Database for Comparing the Adenoma Detection Rate With Air Insufflation, Water Immersion and Water Exchange

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Trial Identification

Brief Title: Comparing the Adenoma Detection Rate With Air Insufflation, Water Immersion and Water Exchange

Official Title: A Randomized, Controlled Trial Comparing the Adenoma Detection Rate With Air Insufflation, Water Immersion and Water Exchange During Colonoscopy

Study ID: NCT01894191

Conditions

Adenoma

Interventions

Air insufflation

water immersion

Water exchange

Study Description

Brief Summary: Interval (missed) cancers and lower than expected mortality reduction of proximal colon cancers in the United States and elsewhere after screening colonoscopy drew attention to quality indicators. Missed adenomas which are more likely to be in the proximal colon may be contributing factors. An independent predictor of the risk of interval cancers is adenoma detection rate. In pilot observations, the investigators showed that water exchange enhanced adenoma detection in the right colon (cecum to hepatic flexure). This prospective, randomized controlled trial will compare water exchange with water immersion and traditional air insufflation in patients undergoing colonoscopy. The investigators test the hypothesis that compared with air insufflation and water immersion, water exchange produces a significantly higher adenoma detection rate in the right colon.

Detailed Description: All of the procedures will be recorded and stored as digital files.