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Brief Title: Step Down Colon Cancer Risk
Official Title: Step Down Colon Cancer Risk: A Pilot Intervention for Colon Cancer Risk Reduction
Study ID: NCT01476631
Brief Summary: Hypothesis 1: Exercise will decrease serum markers in a dose response manner. Hypothesis 2: Participants in the 60 minute intervention will have significantly higher physical activity levels than those in the 30 minute intervention at three months.
Detailed Description: Primary Aim: To conduct a dose response pilot trial of low (30 min/day) or high (60 min/day) dose exercise in men and women at increased risk of colon cancer. The major outcomes are changes in serum levels of four risk-related biomarkers: insulin, C-peptide, IL-6 and PGE-2. Secondary Aim. To compare changes in the secondary outcome of physical activity over three months.
Minimum Age: 50 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Washington University School of Medicine, St. Louis, Missouri, United States
Name: Kathleen Y. Wolin, ScD, FACSM
Affiliation: Washington University School of Medicine
Role: PRINCIPAL_INVESTIGATOR