Spots Global Cancer Trial Database for Dasatinib in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma
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Trial Identification
Brief Title: Dasatinib in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma
Official Title: Phase II Trial of Dasatinib in Patients With Recurrent Glioblastoma Multiforme
Study ID: NCT00423735
Study Description
Brief Summary: This phase II trial studies how well dasatinib works in treating patients with glioblastoma multiforme or gliosarcoma that has come back. Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Detailed Description: PRIMARY OBJECTIVES: I. To determine the therapeutic efficacy of dasatinib in all patients (i.e., stages 1B and 2 combined) with recurrent/progressive glioblastoma (GBM) as measured by 6-month progression-free survival. SECONDARY OBJECTIVES: I. To determine the therapeutic efficacy of dasatinib for stage 1B patients with recurrent/progressive GBM as measured by a hybrid endpoint of 6-month progression-free survival OR objective response of (complete response \[CR\] or partial response \[PR\]) rate. II. To determine patient overall survival. III. To determine the toxicity of dasatinib in the treatment of patients with GBM. IV. To determine radiographic response rate to treatment. V. To determine patient progression-free survival. VI. To explore molecular correlates of clinical outcome. VII. To explore pharmacokinetic correlates of dosing, toxicity, and efficacy. OUTLINE: Patients receive dasatinib orally (PO) twice daily (BID) on days 1-28. Courses repeat every 28 days in the absence of disease progression and unacceptable toxicity. After the completion of study treatment, patients are followed up periodically.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Mobile Infirmary Medical Center, Mobile, Alabama, United States
Arizona Oncology Services Foundation, Scottsdale, Arizona, United States
The University of Arizona Medical Center-University Campus, Tucson, Arizona, United States
Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn, California, United States
Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park, California, United States
Mercy San Juan Medical Center, Carmichael, California, United States
City of Hope Comprehensive Cancer Center, Duarte, California, United States
Glendale Adventist Medical Center, Glendale, California, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California, United States
Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, California, United States
Sutter Medical Center Sacramento, Sacramento, California, United States
University of California Davis Comprehensive Cancer Center, Sacramento, California, United States
Mercy General Hospital Radiation Oncology Center, Sacramento, California, United States
Sutter Cancer Centers Radiation Oncology Services-Vacaville, Vacaville, California, United States
Smilow Cancer Hospital Care Center at Saint Francis, Hartford, Connecticut, United States
Beebe Medical Center, Lewes, Delaware, United States
Christiana Care Health System-Christiana Hospital, Newark, Delaware, United States
Boca Raton Regional Hospital, Boca Raton, Florida, United States
Holy Cross Hospital, Fort Lauderdale, Florida, United States
University of Florida Health Science Center - Gainesville, Gainesville, Florida, United States
Integrated Community Oncology Network-Florida Cancer Center Beaches, Jacksonville Beach, Florida, United States
Baptist MD Anderson Cancer Center, Jacksonville, Florida, United States
Integrated Community Oncology Network-Southside Cancer Center, Jacksonville, Florida, United States
University of Florida Health Science Center - Jacksonville, Jacksonville, Florida, United States
Baptist Medical Center South, Jacksonville, Florida, United States
Jupiter Medical Center, Jupiter, Florida, United States
Mount Sinai Medical Center, Miami Beach, Florida, United States
21st Century Oncology-Orange Park, Orange Park, Florida, United States
21st Century Oncology-Palatka, Palatka, Florida, United States
Bay Medical Center, Panama City, Florida, United States
Integrated Community Oncology Network-Flager Cancer Center, Saint Augustine, Florida, United States
John B Amos Cancer Center, Columbus, Georgia, United States
Memorial Health University Medical Center, Savannah, Georgia, United States
Ingalls Memorial Hospital, Harvey, Illinois, United States
Saint John's Hospital, Springfield, Illinois, United States
Saint Vincent Anderson Regional Hospital/Cancer Center, Anderson, Indiana, United States
Franciscan Saint Francis Health-Beech Grove, Beech Grove, Indiana, United States
IU Health Methodist Hospital, Indianapolis, Indiana, United States
Reid Health, Richmond, Indiana, United States
Menorah Medical Center, Overland Park, Kansas, United States
Saint Luke's South Hospital, Overland Park, Kansas, United States
Kansas City NCI Community Oncology Research Program, Prairie Village, Kansas, United States
Shawnee Mission Medical Center-KCCC, Shawnee Mission, Kansas, United States
The James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky, United States
Union Hospital of Cecil County, Elkton, Maryland, United States
Boston Medical Center, Boston, Massachusetts, United States
Michigan Cancer Research Consortium NCORP, Ann Arbor, Michigan, United States
Saint Joseph Mercy Hospital, Ann Arbor, Michigan, United States
Beaumont Hospital-Dearborn, Dearborn, Michigan, United States
Ascension Saint John Hospital, Detroit, Michigan, United States
Green Bay Oncology - Escanaba, Escanaba, Michigan, United States
Hurley Medical Center, Flint, Michigan, United States
Genesys Regional Medical Center-West Flint Campus, Flint, Michigan, United States
Green Bay Oncology - Iron Mountain, Iron Mountain, Michigan, United States
Allegiance Health, Jackson, Michigan, United States
Bronson Methodist Hospital, Kalamazoo, Michigan, United States
West Michigan Cancer Center, Kalamazoo, Michigan, United States
Borgess Medical Center, Kalamazoo, Michigan, United States
Sparrow Hospital, Lansing, Michigan, United States
Saint Mary Mercy Hospital, Livonia, Michigan, United States
Saint Joseph Mercy Oakland, Pontiac, Michigan, United States
Lake Huron Medical Center, Port Huron, Michigan, United States
Saint Mary's of Michigan, Saginaw, Michigan, United States
Saint John Macomb-Oakland Hospital, Warren, Michigan, United States
Fairview Ridges Hospital, Burnsville, Minnesota, United States
Mercy Hospital, Coon Rapids, Minnesota, United States
Fairview-Southdale Hospital, Edina, Minnesota, United States
Unity Hospital, Fridley, Minnesota, United States
Hutchinson Area Health Care, Hutchinson, Minnesota, United States
Minnesota Oncology Hematology PA-Maplewood, Maplewood, Minnesota, United States
Saint John's Hospital - Healtheast, Maplewood, Minnesota, United States
Abbott-Northwestern Hospital, Minneapolis, Minnesota, United States
Hennepin County Medical Center, Minneapolis, Minnesota, United States
North Memorial Medical Health Center, Robbinsdale, Minnesota, United States
Metro Minnesota Community Oncology Research Consortium, Saint Louis Park, Minnesota, United States
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota, United States
Regions Hospital, Saint Paul, Minnesota, United States
United Hospital, Saint Paul, Minnesota, United States
Saint Francis Regional Medical Center, Shakopee, Minnesota, United States
Ridgeview Medical Center, Waconia, Minnesota, United States
Minnesota Oncology Hematology PA-Woodbury, Woodbury, Minnesota, United States
Singing River Hospital, Pascagoula, Mississippi, United States
Cape Radiation Oncology, Cape Girardeau, Missouri, United States
Centerpoint Medical Center LLC, Independence, Missouri, United States
Truman Medical Center, Kansas City, Missouri, United States
Saint Luke's Hospital of Kansas City, Kansas City, Missouri, United States
Saint Joseph Health Center, Kansas City, Missouri, United States
North Kansas City Hospital, Kansas City, Missouri, United States
Heartland Hematology and Oncology Associates Incorporated, Kansas City, Missouri, United States
Research Medical Center, Kansas City, Missouri, United States
Saint Luke's East - Lee's Summit, Lee's Summit, Missouri, United States
Liberty Radiation Oncology Center, Liberty, Missouri, United States
Heartland Regional Medical Center, Saint Joseph, Missouri, United States
Washington University School of Medicine, Saint Louis, Missouri, United States
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri, United States
Cancer Research for the Ozarks NCORP, Springfield, Missouri, United States
Mercy Hospital Springfield, Springfield, Missouri, United States
CoxHealth South Hospital, Springfield, Missouri, United States
Nebraska Methodist Hospital, Omaha, Nebraska, United States
Renown Regional Medical Center, Reno, Nevada, United States
Cheshire Medical Center-Dartmouth-Hitchcock Keene, Keene, New Hampshire, United States
Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, United States
Cooper Hospital University Medical Center, Camden, New Jersey, United States
Virtua Memorial, Mount Holly, New Jersey, United States
Sparta Cancer Treatment Center, Sparta, New Jersey, United States
Virtua Voorhees, Voorhees, New Jersey, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Highland Hospital, Rochester, New York, United States
University of Rochester, Rochester, New York, United States
Novant Health Presbyterian Medical Center, Charlotte, North Carolina, United States
Rutherford Hospital, Rutherfordton, North Carolina, United States
Summa Akron City Hospital/Cooper Cancer Center, Akron, Ohio, United States
Cleveland Clinic Akron General, Akron, Ohio, United States
Summa Barberton Hospital, Barberton, Ohio, United States
Aultman Health Foundation, Canton, Ohio, United States
University of Cincinnati/Barrett Cancer Center, Cincinnati, Ohio, United States
Grandview Hospital, Dayton, Ohio, United States
Good Samaritan Hospital - Dayton, Dayton, Ohio, United States
Miami Valley Hospital, Dayton, Ohio, United States
Samaritan North Health Center, Dayton, Ohio, United States
Veteran Affairs Medical Center, Dayton, Ohio, United States
Blanchard Valley Hospital, Findlay, Ohio, United States
Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio, United States
Kettering Medical Center, Kettering, Ohio, United States
UH Seidman Cancer Center at Salem Regional Medical Center, Salem, Ohio, United States
Upper Valley Medical Center, Troy, Ohio, United States
University Pointe, West Chester, Ohio, United States
Cancer Treatment Center, Wooster, Ohio, United States
Greene Memorial Hospital, Xenia, Ohio, United States
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
Salem Hospital, Salem, Oregon, United States
Abington Memorial Hospital, Abington, Pennsylvania, United States
Delaware County Memorial Hospital, Drexel Hill, Pennsylvania, United States
Northeast Radiation Oncology Center, Dunmore, Pennsylvania, United States
Adams Cancer Center, Gettysburg, Pennsylvania, United States
Cherry Tree Cancer Center, Hanover, Pennsylvania, United States
Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, United States
Upper Delaware Valley Cancer Center, Milford, Pennsylvania, United States
Reading Hospital, West Reading, Pennsylvania, United States
WellSpan Health-York Hospital, York, Pennsylvania, United States
AnMed Health Hospital, Anderson, South Carolina, United States
Medical University of South Carolina, Charleston, South Carolina, United States
Saint Francis Hospital, Greenville, South Carolina, United States
Greenville Health System Cancer Institute-Eastside, Greenville, South Carolina, United States
Spartanburg Medical Center, Spartanburg, South Carolina, United States
Rapid City Regional Hospital, Rapid City, South Dakota, United States
Wellmont Holston Valley Hospital and Medical Center, Kingsport, Tennessee, United States
Thompson Cancer Survival Center, Knoxville, Tennessee, United States
Thompson Cancer Survival Center - West, Knoxville, Tennessee, United States
Thompson Cancer Survival Center at Methodist, Oak Ridge, Tennessee, United States
University of Texas Medical Branch, Galveston, Texas, United States
M D Anderson Cancer Center, Houston, Texas, United States
Covenant Medical Center-Lakeside, Lubbock, Texas, United States
American Fork Hospital / Huntsman Intermountain Cancer Center, American Fork, Utah, United States
Sandra L Maxwell Cancer Center, Cedar City, Utah, United States
Logan Regional Hospital, Logan, Utah, United States
Cottonwood Hospital Medical Center, Murray, Utah, United States
Intermountain Medical Center, Murray, Utah, United States
McKay-Dee Hospital Center, Ogden, Utah, United States
Utah Valley Regional Medical Center, Provo, Utah, United States
Dixie Medical Center Regional Cancer Center, Saint George, Utah, United States
Intermountain Health Care, Salt Lake City, Utah, United States
Utah Cancer Specialists-Salt Lake City, Salt Lake City, Utah, United States
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah, United States
LDS Hospital, Salt Lake City, Utah, United States
University of Vermont Medical Center, Burlington, Vermont, United States
University of Vermont College of Medicine, Burlington, Vermont, United States
Norris Cotton Cancer Center-North, Saint Johnsbury, Vermont, United States
Southwest VA Regional Cancer Center, Norton, Virginia, United States
Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, United States
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima, Washington, United States
Wheeling Hospital/Schiffler Cancer Center, Wheeling, West Virginia, United States
Green Bay Oncology at Saint Vincent Hospital, Green Bay, Wisconsin, United States
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin, United States
Green Bay Oncology Limited at Saint Mary's Hospital, Green Bay, Wisconsin, United States
Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay, Wisconsin, United States
Gundersen Lutheran Medical Center, La Crosse, Wisconsin, United States
University of Wisconsin Hospital and Clinics, Madison, Wisconsin, United States
Bay Area Medical Center, Marinette, Wisconsin, United States
Froedtert and the Medical College of Wisconsin, Milwaukee, Wisconsin, United States
ProHealth Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin, United States
Green Bay Oncology - Oconto Falls, Oconto Falls, Wisconsin, United States
Green Bay Oncology - Sturgeon Bay, Sturgeon Bay, Wisconsin, United States
ProHealth Waukesha Memorial Hospital, Waukesha, Wisconsin, United States
London Regional Cancer Program, London, Ontario, Canada
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Quebec City, Quebec, Canada
Allan Blair Cancer Centre, Regina, Saskatchewan, Canada
King Faisal Specialist Hospital and Research Centre, Riyadh, , Saudi Arabia
Contact Details
Name: Andrew Lassman
Affiliation: NRG Oncology
Role: PRINCIPAL_INVESTIGATOR
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