Spots Global Cancer Trial Database for KV-CBCT and Ultrasound Imaging in Guiding Radiation Therapy in Patients With Prostate, Liver, or Pancreatic Cancer

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Trial Identification

Brief Title: KV-CBCT and Ultrasound Imaging in Guiding Radiation Therapy in Patients With Prostate, Liver, or Pancreatic Cancer

Official Title: Integrated 3D X-ray and Ultrasound Guided Radiation Therapy of Soft Tissue Targets

Study ID: NCT02337465

Conditions

Adult Liver Carcinoma

Malignant Pancreatic Neoplasm

Prostate Carcinoma

Interventions

Cone-Beam Computed Tomography

3-Dimensional Ultrasound-Guided Radiation Therapy

Study Description

Brief Summary: This clinical trial studies if kilo-voltage cone beam computed tomography (KV-CBCT) and ultrasound imaging works in guiding radiation therapy in patients with prostate, liver, or pancreatic cancer. Computer systems, such as KV-CBCT and ultrasound imaging, allow doctors to create a 3-dimensional picture of the tumor may help in planning radiation therapy and may result in more tumor cells being killed.

Detailed Description: PRIMARY OBJECTIVES: I. To investigate the feasibility of combining on-board cone beam computed tomography (CBCT) with ultrasound imaging to overcome the shortcomings of CBCT or ultrasound imaging alone for imaging guided radiotherapy delivery. OUTLINE: Patients undergo ultrasound imaging prior to and during radiation therapy. Patients also undergo kilo-voltage cone beam computed tomography prior to radiation therapy. Update (2021/02/04): Removed secondary outcome "Incidence of Adverse Events Related to the Ultrasound Probe". Per PI: Study initially intended to involve a non-FDA approved probe for use with liver patients but removed this section.