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Brief Title: Dose Finding Study of GH35 in Patients With Advanced Solid Tumors
Official Title: A Phase I Study Evaluating the Safety, Tolerability, Pharmacokinetic Characteristics, and Primary Antitumor Activity of GH35 in Patients With Advanced Solid Tumors With KRAS Mutation
Study ID: NCT05010694
Brief Summary: Evaluate the safety and tolerability of GH35 in patients with KRAS mutant advanced solid tumors. Estimate the maximum tolerated dose (MTD) and/or a recommended phase 2 dose (RP2D) in patients with KRAS mutant advanced solid tumors.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Fudan University Zhongshan Hospital, Shanghai, Shanghai, China
Shanghai Chest Hospital, Shanghai, Shanghai, China
Name: Baohui Han, Professor
Affiliation: Shanghai Chest Hospital
Role: PRINCIPAL_INVESTIGATOR