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Brief Title: Everolimus and Letrozole or Hormonal Therapy to Treat Endometrial Cancer
Official Title: A Randomized Phase II Trial of Everolimus and Letrozole or Hormonal Therapy (Tamoxifen/Medroxyprogesterone Acetate) in Women With Advanced, Recurrent, or Persistent Endometria Carcinoma
Study ID: NCT02228681
Brief Summary: The main purpose of this study is to evaluate the effectiveness of the combination of the drugs Everolimus and Letrozole compared to Tamoxifen and Medroxyprogesterone acetate in treating endometrial cancer and to determine the types and severity of side effects caused by treatment with these drug combinations.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
University of Colorado - Anschutz Cancer Pavilion, Aurora, Colorado, United States
University of Miami - Sylvester Comprehensive Cancer Center, Miami, Florida, United States
John B. Amos Cancer Center, Columbus, Georgia, United States
Memorial Health University Medical Center, Savannah, Georgia, United States
Maine Medical Center, Scarborough, Maine, United States
Johns Hopkins, Baltimore, Maryland, United States
University of Massachusetts Memorial Center, Worcester, Massachusetts, United States
Sanford Clinic North - Bemidji, Bemidji, Minnesota, United States
St. Dominic-Jackson Memorial Hospital, Jackson, Mississippi, United States
University of Mississippi Medical Center, Jackson, Mississippi, United States
Women's Cancer Center of Nevada, Las Vegas, Nevada, United States
New Mexico Cancer Alliance, Albuquerque, New Mexico, United States
Memorial Medical Center-Cancer Center, Albuquerque, New Mexico, United States
Women's Cancer Care Associates, Albany, New York, United States
SUNY Downstate Medical Center, Brooklyn, New York, United States
Sanford Roger Maris Cancer Center, Fargo, North Dakota, United States
University Hospital Case Medical Center, Cleveland, Ohio, United States
Ohio State University, Columbus, Ohio, United States
University of Oklahoma, Oklahoma City, Oklahoma, United States
Abington Memorial Hospital, Abington, Pennsylvania, United States
The University of Pennsylvania, Philadelphia, Pennsylvania, United States
Magee Women's Hospital of UPMC, Pittsburgh, Pennsylvania, United States
Women & Infants Hospital of Rhode Island, Providence, Rhode Island, United States
Sanford Medical Center - Sioux Falls, Sioux Falls, South Dakota, United States
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Huntsman Cancer Institute, Salt Lake City, Utah, United States
Name: Brian Slomovitz, MD
Affiliation: Gynecologic Oncology Group
Role: STUDY_CHAIR