Spots Global Cancer Trial Database for Study of Advanced Bulky Malignancies With Spatially Fractioned Radiation Therapy

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Trial Identification

Brief Title: Study of Advanced Bulky Malignancies With Spatially Fractioned Radiation Therapy

Official Title: Treatment of Advanced Bulky Malignancies With Spatially Fractioned Radiation Therapy A Phase II Randomized Trial

Study ID: NCT00765570

Conditions

Advanced Bulky Malignancies

Interventions

Spatially Fractioned Radiation Therapy

Treatment Group 1

Standard radiation

Study Description

Brief Summary: Expand clinical literature on the use of Grid radiation with conventional external beam therapy. Vast majority of therapy is for palliative care to provide relief from pain, but has also shown a reduction in the size of tumor mass.

Detailed Description: This study will evaluate response to radiation therapy by a large bulky tumor is influenced by adding a single dose of 15 Gy grid radiotherapy. To accomplish this, patients with large bulky tumors in the lung, abdomen or pelvis will be randomized to receive either standard palliative radiation or palliative radiation plus a single fraction of grid radiation. Tumor response, pain relief and duration of response, and pain control will be monitored. Toxicity of treatment will also be followed. The hypothesis of this study is that grid radiation will produce a significant improvement in tumor response and pain control that produces no further increase in acute or late toxicity.