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Spots Global Cancer Trial Database for Study of Amblyomin-X in Advanced Solid Tumor

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Trial Identification

Brief Title: Study of Amblyomin-X in Advanced Solid Tumor

Official Title: Phase I Study (First in Humans) of the Amblyomin-X in the Treatment of Patients With Advanced Solid Tumors Refractory or Without Indication / Access to Standard Treatment

Study ID: NCT03120130

Conditions

Advanced Cancer

Interventions

Amblyomin-X

Study Description

Brief Summary: Amblyomin-X is an inhibitor of Factor Xa that also acts as an apoptotic agent for tumor cells. In the case of in vitro assays, Amblyomin-X induces tumor cells to death and does not affect the viability of normal cells. When in vivo assays were performed on mice bearing tumors, treatment with Amblyomin-X caused a significant reduction in tumor mass and number of metastases.

Detailed Description: This trial will be the first clinical study in humans with the product, which until then has been studied only in experimental models. Given the current epidemiological impact of cancer and the need to improve its systemic treatment, making it available to a larger portion of the Brazilian population, it is proposed to conduct the first Amblyomin-X study in cancer patients, more specifically those with advanced solid tumors For which there is no contraindicated or inaccessible therapeutic option established as the standard at the time of inclusion in the study.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

União Química Farmacêutica Nacional, Sao Paulo, SP, Brazil

Contact Details

Name: Paula F Santos

Affiliation: União Quimica

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

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