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Brief Title: A Study of BMS-986406 as Monotherapy and Combination Therapies in Participants With Advanced Tumors
Official Title: A Phase 1 First-in-human Study of BMS-986406 as Monotherapy and Combination Therapies in Participants With Advanced Malignant Tumors
Study ID: NCT05298592
Brief Summary: The purpose of this study is to assess the safety and tolerability of BMS-986406 administered alone, in combination with nivolumab, or in combination with nivolumab and platinum-doublet chemotherapy (PDCT) in participants with advanced tumors.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Local Institution - 0021, Birmingham, Alabama, United States
University California San Diego Moores Cancer Center, La Jolla, California, United States
The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate, Los Angeles, California, United States
UCLA Health, Los Angeles, California, United States
Yale Cancer Center, New Haven, Connecticut, United States
Local Institution - 0001, Hackensack, New Jersey, United States
Carolina BioOncology Institute, PLLC, Huntersville, North Carolina, United States
Sanford Cancer Center, Sioux Falls, South Dakota, United States
Mary Crowley Cancer Research - Medical City Hospital, Dallas, Texas, United States
VCU Massey Cancer Center, Richmond, Virginia, United States
Local Institution - 0029, Viedma, Rio Negro, Argentina
Local Institution - 0023, Rosario, Santa Fe, Argentina
Local Institution - 0028, Buenos Aires, , Argentina
Local Institution - 0032, Cordoba, , Argentina
Local Institution - 0018, Brussel (Jette), Brussel, Belgium
Local Institution - 0015, Edegem, MA, Belgium
Local Institution - 0012, Brussels, , Belgium
Local Institution - 0031, Kashiwa-shi, Chiba, Japan
Local Institution - 0026, Seongnam, Gyeonggi-do, Korea, Republic of
Local Institution - 0024, Seoul, , Korea, Republic of
Local Institution - 0027, Seoul, , Korea, Republic of
Local Institution - 0025, Seoul, , Korea, Republic of
Local Institution - 0008, Malaga, Andaluca, Spain
Local Institution - 0022, Barcelona, , Spain
Local Institution - 0030, Barcelona, , Spain
Hospital Universitario Vall dHebron, Barcelona, , Spain
Institut Catala dOncologia ICO - Hospital Duran i Reynals Location, Barcelona, , Spain
Local Institution - 0014, Madrid, , Spain
Local Institution - 0009, Madrid, , Spain
Local Institution - 0016, Madrid, , Spain
Local Institution - 0033, Pamplona, , Spain
Name: Bristol-Myers Squibb
Affiliation: Bristol-Myers Squibb
Role: STUDY_DIRECTOR