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Spots Global Cancer Trial Database for Study of Pembrolizumab Plus Chemotherapy in Patients With Advanced Cancer (PembroPlus)

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Study of Pembrolizumab Plus Chemotherapy in Patients With Advanced Cancer (PembroPlus)

Official Title: A Phase Ib/II Study of Pembrolizumab Plus Chemotherapy in Patients With Advanced Cancer (PembroPlus)

Study ID: NCT02331251

Study Description

Brief Summary: The Phase Ib and II cohorts will enroll patients with metistatic solid tumors. Phase II only will enroll the following patients: Patients with metastatic sarcoma to be enrolled in the following 4 arms: pembro plus gemcitabine, pembro plus gemcitabine and docetaxel, pembro plus gemcitabine and vinorelbine, and pembro plus liposomal doxorubicin. Patients with metastatic pancreatic adenocarcinoma to be enrolled in the pembro plus gemcitabine and nab-paclitaxel arm. Patients with extensive-stage small cell lung cancer to be enrolled in the pembro plus irinotecan arm. Patients with ER+ breast cancer to be enrolled in the pembro and vinorelbine arm. Patients with ovarian cancer to be enrolled in the pembroplus liposomal doxorubicin arm. Patients with metastatic TNBC (ER/PR/HER2 negative) to be enrolled in the pembro plus gemcitabine arm.

Detailed Description: Pembrolizumab 2mg/kg administered intravenously over 30 minutes every 3 weeks.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Cancer Treatment Center of America @ Western Regional Medical Center, Goodyear, Arizona, United States

Western Regional Medical Center, Goodyear, Arizona, United States

Contact Details

Name: Ashish Sangal, MD

Affiliation: Western Regional Medical Center

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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