Spots Global Cancer Trial Database for Umbrella Study for Single Patient Treatments in Oncology

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Trial Identification

Brief Title: Umbrella Study for Single Patient Treatments in Oncology

Official Title: UNIQUE: Umbrella N-of-1 Tumor Trials - Umbrella Protocol for Oncology Single Patient Protocols

Study ID: NCT06285500

Conditions

Advanced Cancer

Rare Diseases

Interventions

Patient-specific treatments

Study Description

Brief Summary: The purpose of this study is to collect data on how advanced and rare cancers respond to biomarker-based treatments.

Detailed Description: The UNIQUE umbrella protocol is an overarching framework to study precision medicine in patients with precise molecular data, who have exhausted all established treatment options and who are not eligible for any of the ongoing trials. There is no additional visit or procedure required to participate in this study. Participants who have received/who may receive the following treatments may join the study and will be assigned to a study cohort (group): * Group 1 - Health Canada approved/marketed drug(s) used on or off-label as Standard of Care (SOC) * Group 2 - Drugs accessed from Special Access Program (SAP) * Group 3 - Non-marketed investigational agents Under the UNIQUE framework, data from participants will be evaluated. The following data will be collected: * Demographic data (for example: sex, race, month and year of birth) * Medical history * Cancer characteristics including biomarkers * Treatment history * response to treatment