Spots Global Cancer Trial Database for Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Colorectal Cancer

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Trial Identification

Brief Title: Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Colorectal Cancer

Official Title: Phase II Randomized Comparison Clinical Trial of Target Activated CIK for Advanced Colorectal Cancer

Study ID: NCT03524274

Conditions

Advanced Colorectal Cancer

Interventions

Activated CIK and CD3-MUC1 Bispecific Antibody in Treating colorectal cancer

Cryotherapy

Study Description

Brief Summary: This is a phase II Randomized comparison clinical trial of activated CIK armed with anti-CD3-MUC1 bispecific antibody for advanced colorectal cancer. And the aim of this research is to study the clinical efficacy and safety of activated CIK armed with anti-CD3-MUC1 bispecific antibody for colorectal cancer.

Detailed Description: Primary colorectal carcinoma is one of the most common malignancies in China, Immunotherapy is considered to be one of the most promising means of human against cancer. This is a phase II clinical trial of single- center, The investigators plan to recruit for 90 patients with advanced colorectal cancer,and all patients are divided into three groups.one group will receive cryotherapy, one group will receive conventional therapy，and the rest one will receive mixed liquor of activated CIK and anti-CD3-MUC1 bispecific antibody together with cryotherapy. The result of this study was statistic and analysed with the record of Response Evaluation Criteria In Solid Tumors(RECIST1.1) evaluation standard.