Spots Global Cancer Trial Database for Molecular Study and Precision Medicine for Colorectal Cancer

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Trial Identification

Brief Title: Molecular Study and Precision Medicine for Colorectal Cancer

Official Title: Precision Medicine for Advanced or Recurrent Colorectal Cancer Directed by High-throughput Sequencing and Tumor Organoids Model

Study ID: NCT05883683

Conditions

Advanced Colorectal Carcinoma

Recurrent Colorectal Carcinoma

Interventions

Molecular Profiling & drug testing in tumor organoids and PDXs

Study Description

Brief Summary: Researchers collect specimens from advanced or recurrent colorectal cancer (CRC) patients to conduct molecular profiling and establish tumor organoids (PDOs)/ patient-derived xenografts (PDXs). The aim of this study is to identify clinical actionable targets and predict in vivo response of the tumor to targeted drugs by using PDOs/ PDXs. And the above-mentioned studies will provide the patients with potential personalized cancer treatment options.

Detailed Description: Patient-derived organoid is a model that can recapitulate the histology and behavior of the cancer from which it is derived, and is increasingly used as a tool for drug development in pre-clinical settings. Clinical treatment option of colorectal cancer now is quite limited. By molecular profiling, clinical actionable alterations may be identified. And according to the genomic investigation results, we can find the matched targeted drugs, following further testing in the organoids and PDXs. This will provide an opportunity to guide the precision medicine.