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Spots Global Cancer Trial Database for Evaluate the Safety and Efficacy of Toripalimab Combined With Bevacizumab Versus Sorafenib Therapy for HCC

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Trial Identification

Brief Title: Evaluate the Safety and Efficacy of Toripalimab Combined With Bevacizumab Versus Sorafenib Therapy for HCC

Official Title: A Randomized, Open-label, Multi-center Phase III Clinical Study to Evaluate the Safety and Efficacy of Toripalimab (JS001) Combined With Bevacizumab Versus Sorafenib as First-line Therapy for Advanced Hepatocellular Carcinoma

Study ID: NCT04723004

Study Description

Brief Summary: This is a prospective, randomized, open-label, parallel-group, active controlled, multi-center phase III registration clinical study to observe, compare and evaluate the efficacy and safety of Toripalimab (hereafter referred to as JS001) combined with Bevacizumab versus Sorafenib as the first-line therapy for advanced HCC This study will enroll the patients with locally advanced or metastatic hepatocellular carcinoma who could not be radically cured and not receive any prior systemic therapy. The study will use PFS and OS as the co-primary endpoints, with approximately 280 patients planned to be enrolled.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

The First Affiliated Hospital of Bengbu Medical college, Bengbu, Anhui, China

Anhui Cancer Hospital, Hefei, Anhui, China

Anhui Provincial Hospital, Hefei, Anhui, China

The Second Hospital of Anhui Medical University, Hefei, Anhui, China

Beijing Cancer Hospital, Beijing, Beijing, China

China PLA General Hospital, Beijing, Beijing, China

Peking Union Medical College Hospital, Beijing, Beijing, China

Army Medical Center of PLA, Chongqing, Chongqing, China

The First Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing, China

The Southwest Hospital Of AMU, Chongqing, Chongqing, China

The Frist Hospital of Lanzhou University, Lanzhou, Gansu, China

Gansu Wuwei Tumor Hospital, Wuwei, Gansu, China

The First Peoples Hospital of Foshan, Foshan, Guangdong, China

Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong, China

SSun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China

Yuebei People's Hospital, Shaoguan, Guangdong, China

Hainan General Hospital, Haikou, Hainan, China

Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China

he First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

Henan Provincial Cancer Hospital, Zhengzhou, Henan, China

Hubei Cancer Hospital, Wuhan, Hubei, China

Hunan Cancer Hospital, Changsha, Hunan, China

Xiangya Hospital of Central South University, Changsha, Hunan, China

NanJing Drum Tower Hospital, Nanjing, Jiangsu, China

Nantong Tumor Hospital, Nantong, Jiangsu, China

The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China

The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China

The first Affiliated hospital of Nanchang University, Nanchang, Jiangxi, China

The Second Affiliated hospital of Nanchang University, Nanchang, Jiangxi, China

Jilin Cancer Hospital, Changchun, Jilin, China

Jilin Guowen Hospital, Changchun, Jilin, China

Liaoning cancer hospital, Shenyang, Liaoning, China

Shandong Cancer Hospital, Jinan, Shandong, China

The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China

First Affiliated Hospital of Xian Jiaotong University, Xi'an, Shanxi, China

Xi'an International Medical Center Hospital, Xi'an, Shanxi, China

Sichuan Cancer Hospital, Chengdu, Sichuan, China

West China Hospital,Sichuan University, Chengdu, Sichuan, China

Kaohsiung Medical University Chung-Ho Memorial Hospital, Gaoxiong, Taiwan, China

MacKay Memorial Hospital, Taibei, Taiwan, China

Changhua Christian Hospital, Zhanghua, Taiwan, China

Tianjin Medical University Cancer Institute & Hospital, Tianjin, Tianjin, China

Yunnan Cancer Hospital, Kunming, Yunnan, China

ShuLan(HangZhou) Hospital, Hangzhou, Zhejiang, China

The First Affiliated Hospital,Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

ZheJiang Cancer Hospital, Hangzhou, Zhejiang, China

ZheJiang Provincial People's Hospital, Hangzhou, Zhejiang, China

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

Tongji Hospital Tongji Medical College Of HUST, Wuhan, Zhejiang, China

Xiehe Hospital Tongji Medical College Of HUST, Wuhan, Zhejiang, China

Zhongnan Hospital of Wuhan University, Wuhan, Zhejiang, China

Jia Fan, Shanghai, , China

Curie Oncology, Singapore, , Singapore

Tan Tock Seng Hospital, Singapore, , Singapore

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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