Spots Global Cancer Trial Database for Study of GPC-3 CAR-T Cells in Treating With Hepatocellular Carcinoma

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Trial Identification

Brief Title: Study of GPC-3 CAR-T Cells in Treating With Hepatocellular Carcinoma

Official Title: Study of GPC-3 CAR-T Cells in Advanced Hepatocellular Carcinoma

Study ID: NCT05620706

Conditions

Advanced Hepatocellular Carcinoma

Interventions

GPC3 CAR-T cells

Study Description

Brief Summary: Hepatocellular carcinoma is a highly heterogeneous disease. Treatment strategies for advanced hepatocellular carcinoma are limited. Phosphatidylinositol proteoglycan 3 (GPC3) is a heparan sulfate glycoprotein (HSPG) on the surface of the cell membrane. It is highly expressed in liver cancer tissues, but hardly expressed in normal liver tissues. It is an ideal target for tumor treatment. Investigators aimed to test the safety and efficacy of GPC3 CAR-T cells in patients with advanced hepatocellular carcinoma.

Detailed Description: Hepatocellular carcinoma is a highly heterogeneous disease. Treatment strategies for advanced hepatocellular carcinoma are limited. Resulting in a poor prognosis. Phosphatidylinositol proteoglycan 3 (GPC3) is a heparan sulfate glycoprotein (HSPG) on the surface of the cell membrane. It is highly expressed in liver cancer tissues, but hardly expressed in normal liver tissues. It is an ideal target for tumor treatment. Investigators aimed to test the safety and efficacy of GPC3 CAR-T cells in patients with advanced hepatocellular carcinoma.