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Brief Title: Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Kidney Cancer
Official Title: Phase II Randomized Comparison Clinical Trial of Target Activated CIK for Advanced Kidney Cancer
Study ID: NCT03540199
Brief Summary: This is a phase II Randomized comparison clinical trial of activated CIK armed with anti-CD3-MUC1 bispecific antibody for advanced kidney cancer. And the aim of this research is to study the clinical efficacy and safety of activated CIK armed with anti-CD3-MUC1 bispecific antibody for kidney cancer.
Detailed Description: Primary kidney carcinoma is one of the most common malignancies in China,immunotherapy is considered to be one of the most promising means of human against cancer. This is a phase II clinical trial of single- center, The investigators plan to recruit for 90 patients with advanced kidney cancer,and all patients are divided into three groups.one group will receive cryotherapy, one group will receive conventional therapy,and the rest one will receive mixed liquor of activated CIK and anti-CD3-MUC1 bispecific antibody together with cryotherapy. The result of this study was statistic and analysed with the record of Response Evaluation Criteria In Solid Tumors(RECIST1.1) evaluation standard.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Institutional Review Board of Guangzhou Fuda Cancer Hospital, Guangzhou, Guangdong, China
Name: Jibing Chen, Doctor
Affiliation: Guangzhou Fuda Cancer Hospital
Role: STUDY_CHAIR