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Brief Title: A Phase 1b Study Evaluating AMG 232 Alone and in Combination With Trametinib in Acute Myeloid Leukemia
Official Title: A Phase 1b Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AMG 232 Alone and in Combination With Trametinib in Adult Subjects With Relapsed/Refractory Acute Myeloid Leukemia
Study ID: NCT02016729
Brief Summary: Open-label, sequential dose escalation and expansion study of AMG 232 in subjects with acute myeloid leukemia.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Research Site, Birmingham, Alabama, United States
Research Site, Buffalo, New York, United States
Research Site, Charlotte, North Carolina, United States
Research Site, Salt Lake City, Utah, United States
Research Site, Seattle, Washington, United States
Name: MD
Affiliation: Amgen
Role: STUDY_DIRECTOR