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Spots Global Cancer Trial Database for Sunitinib in Treating Patients With Advanced Malignant Pleural Mesothelioma

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Trial Identification

Brief Title: Sunitinib in Treating Patients With Advanced Malignant Pleural Mesothelioma

Official Title: A Phase II Study of Sunitinib (SU11248; NSC 736511; IND 74019) in Patients With Advanced Malignant Pleural Mesothelioma

Study ID: NCT00392444

Interventions

sunitinib malate

Study Description

Brief Summary: This phase II trial is studying how well sunitinib works in treating patients with advanced malignant mesothelioma of the pleura. Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for their growth.

Detailed Description: PRIMARY OBJECTIVES: I. Assess the efficacy of sunitinib malate, in terms of response rate (complete and partial), in patients with malignant pleural mesothelioma. II. Assess the toxicity, safety, and tolerability of this drug in these patients. III. Assess the duration of response or stable disease, stable disease rate, progression-free survival, and median and overall survival rates. OUTLINE: This is a multicenter, nonrandomized, open-label study. Patients are stratified according to prior cytotoxic chemotherapy (yes vs no). Patients receive oral sunitinib malate once daily on days 1-28. Treatment repeats every 6 weeks in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed at 4 weeks and then every 3 months thereafter.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

National Cancer Institute of Canada Clinical Trials Group, Kingston, Ontario, Canada

Contact Details

Name: Scott Laurie

Affiliation: Canadian Cancer Trials Group

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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