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Spots Global Cancer Trial Database for Pazopanib in Treating Patients With Malignant Pleural Mesothelioma

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Trial Identification

Brief Title: Pazopanib in Treating Patients With Malignant Pleural Mesothelioma

Official Title: Phase II Study of GW786034 in Patients With Malignant Pleural Mesothelioma

Study ID: NCT00459862

Study Description

Brief Summary: This phase II trial is studying the side effects and how well pazopanib works in treating patients with malignant pleural mesothelioma. Pazopanib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.

Detailed Description: PRIMARY OBJECTIVES: I. Determine the effect of pazopanib hydrochloride on the proportion of patients with malignant pleural mesothelioma who are progression-free at 6 months based on the RECIST criteria. II. Determine the clinical toxicities of this drug in this patient population. SECONDARY OBJECTIVES: I. Determine the objective tumor response status in these patients as measured by the RECIST criteria or the modified RECIST criteria. II. Determine the response rate in patients treated with this drug. III. Determine the effect of this drug on overall survival and time to progression in these patients. IV. Assess predictive markers of activity of this drug in these patients. V. Assess serologic markers of target inhibition by this drug in these patients. VI. Determine the clinical toxicities of this drug in this patient population. OUTLINE: This is a multicenter study. Patients receive oral pazopanib hydrochloride once daily on days 1-21. Treatment repeats every 21 days for 2 years in the absence of disease progression or unacceptable toxicity. Blood is collected at baseline and prior to each course of therapy and analyzed for markers of angiogenesis. After completion of study therapy, patients are followed every 3 months.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

North Central Cancer Treatment Group, Rochester, Minnesota, United States

Contact Details

Name: Julian Molina

Affiliation: North Central Cancer Treatment Group

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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