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Brief Title: Clinical Study of HMPL-653 in Treatment of Advanced Malignant Solid Tumors and TGCT
Official Title: A Multicenter, Open-label, Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HMPL-653 in Treatment of Patients With Advanced Malignant Solid Tumors and Tenosynovial Giant Cell Tumor
Study ID: NCT05277454
Brief Summary: To evaluate the safety and tolerability of HMPL-653 in patients with advanced solid tumors who have failure of standard of care or can not tolerate standard of care or those with TGCT, and to determine the maximum tolerated dose (MTD) and/or the recommended phase II clinical study dose (RP2D) of HMPL-653 in patients with advanced solid tumors.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Jilin Provincial Cancer Hospital, Chang chun, , China
Harbin Medical University Cancer Hospital, Harbin, , China
Linyi Cancer Hospital, Linyi, , China
Henan Cancer Hospital, Zhengzhou, , China
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, , China
Name: Ying Cheng, Prof
Affiliation: Jilin Provincial Cancer Hospital
Role: PRINCIPAL_INVESTIGATOR