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Brief Title: A Efficacy and Safety Study of Anlotinib Hydrochloride Capsule Combined With Chemotherapy Versus Placebo Combined With Chemotherapy as First-line Treatment in Subjects With Advanced Non-squamous Cell Non-small Cell Lung Cancer
Official Title: A Randomized, Double-blind, Multicenter Phase III Study of Anlotinib Hydrochloride Capsule Combined With Chemotherapy Versus Placebo Combined With Chemotherapy as First-line Treatment in Subjects With Advanced Non-squamous Cell Non-small Cell Lung Cancer
Study ID: NCT04439890
Brief Summary: This is a randomized, double-blind, multicenter phase III clinical study to evaluate efficacy and safety of anlotinib hydrochloride capsule combined with chemotherapy versus placebo combined with chemotherapy as first-line treatment in subjects with advanced non-squamous cell non-small cell lung cancer.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
Anhui Chest Hospital, Hefei, Anhui, China
Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China
Beijing Chest Hospital, Capital Medical University, Beijing, Beijing, China
Peking University Third Hospital, Beijing, Beijing, China
The Sixth Medical Center of Chinese PLA General Hospital, Beijing, Beijing, China
Xuanwu Hospital of Capital Medical University, Beijing, Beijing, China
Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, Beijing, China
The First Affiliated Hospital of Chongqing Medical University, Chongqing, Chongqing, China
The Second Affiliated Hospital of Chinese PLA Army Medical University, Chongqing, Chongqing, China
Fujian Cancer Hospital, Fuzhou, Fujian, China
The First Hospital of Lanzhou University, Lanzhou, Gansu, China
Gansu Wuwei Tumor Hospital, Wuwei, Gansu, China
The Fifth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong, China
Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
Meizhou People's Hospital, Meizhou, Guangdong, China
Guangxi Medical University Affiliated Tumor Hospital, Nanning, Guangxi, China
The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
Xingtai People's Hospital, Xingtai, Hebei, China
Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China
First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, China
The First Affiliated Hospital of Xinxiang Medical College, Xinxiang, Henan, China
Henan Cancer Hospital, Zhengzhou, Henan, China
Huazhong University of Science Tongji Hospital, Tongji Medical College, Wuhan, Hubei, China
Xiangya Hospital Central South University, Changsha, Hunan, China
Hunan Cancer Hospital, Changsha, Hunan, China
Changzhou Second People's Hospital, Changzhou, Jiangsu, China
Lianyungang First People's Hospital, Lianyungang, Jiangsu, China
Affiliated Hospital of Nantong University, Nantong, Jiangsu, China
The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China
Subei People's Hospital, Yangzhou, Jiangsu, China
The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
The Second Hospital of Jilin University, Changchun, Jilin, China
The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China
The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China
Liaoning Cancer Hospital, Shenyang, Liaoning, China
The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Neimenggu, China
Ningxia Medical University General Hospital, Yinchuan, Ningxia, China
Qilu Hospital of Shandong University, Jinan, Shandong, China
Affiliated Hospital of Jining Medical University, Jining, Shandong, China
Linyi Cancer Hospital, Linyi, Shandong, China
Tengzhou Central People's Hospital, Tengzhou, Shandong, China
Fudan University Cancer Hospital, Shanghai, Shanghai, China
Shanghai Chest Hospital, Shanghai, Shanghai, China
Linfen Central Hospital, Linfen, Shanxi, China
The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
Tangdu Hospital, The Fourth Military Medical University of PLA, Xi'an, Shanxi, China
First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, China
Dazhou Central Hospital, Dazhou, Sichuan, China
Tianjin Chest Hospital, Tianjin, Tianjin, China
Tianjin Medical University General Hospital, Tianjin, Tianjin, China
Tianjin Cancer Hospital, Tianjin, Tianjin, China
Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China
Yunnan Cancer Hospital, Kunming, Yunnan, China
Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Ruian People's Hospital, Ruian, Zhejiang, China