Spots Global Cancer Trial Database for Safety, Efficacy, and Tolerability of BOS172738 in Patients With Advanced Rearranged During Transfection (RET) Gene-Altered Tumors
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Trial Identification
Brief Title: Safety, Efficacy, and Tolerability of BOS172738 in Patients With Advanced Rearranged During Transfection (RET) Gene-Altered Tumors
Official Title: A Phase 1 Study of BOS172738 in Patients With Advanced Solid Tumors With RET Gene Alterations Including Non-Small Cell Lung Cancer (NSCLC) and Medullary Thyroid Cancer (MTC)
Study ID: NCT03780517
Conditions
Interventions
Study Description
Brief Summary: This study will be conducted to assess the safety and tolerability of BOS172738 when administered to patients with advanced solid tumors with rearranged during transfection (RET) gene alterations and also to establish the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) of BOS172738.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
MD Anderson Cancer Center, Houston, Texas, United States
Institut Jules Bordet, Bruxelles, , Belgium
UZ Leuven, Leuven, , Belgium
Institut Bergonié, Bordeaux, , France
Centre Léon Bérard, Lyon, , France
Hôpital Pitié-Salpêtrière, Paris, , France
Institut Gustave Roussy, Villejuif, , France
Prince of Wales Hospital, Hong Kong, , Hong Kong
Chungbuk National University Hospital, Cheongju-si, , Korea, Republic of
Seoul National University Bundang Hospital, Gyeonggi-do, , Korea, Republic of
Asan Medical Center, Seoul, , Korea, Republic of
Korea University Anam Hospital, Seoul, , Korea, Republic of
Severance Hospital, Yonsei University College of Medicine, Seoul, , Korea, Republic of
Hospital Universitario Virgen de la Victoria, Málaga, Andalucia, Spain
Hospital Germans Trias i Pujol, Badalona, , Spain
Instituto Oncológico Dr. Rosell, S.L., Barcelona, , Spain
Start Madrid - Ciocc, Madrid, , Spain
START MADRID-FJD, Hospital Fundación Jiménez Díaz, Madrid, , Spain
Taichung Veterans General Hospital, Taichung, , Taiwan
National Taiwan University Hospital, Taipei, , Taiwan
Contact Details
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