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Brief Title: Study of MLN4924 in Adult Patients With Nonhematologic Malignancies
Official Title: An Open-Label, Dose Escalation, Phase I Study of MLN4924, a Novel Inhibitor of Nedd8-Activating Enzyme, in Adult Patients With Nonhematologic Malignancies
Study ID: NCT00677170
Brief Summary: This study is an open-label, multicenter, Phase 1, dose escalation study of MLN4924 in adult patients with nonhematologic malignancies. This study will be the first to administer MLN4924 in humans. The patient population will consist of adults with any form of nonhematologic malignancy for which standard, curative, life prolonging, or palliative treatment does not exist or is no longer effective.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Emory University Hospital, Atlanta, Georgia, United States
Cancer Therapy & Research Center at the UT Health Science Center, San Antonio, Texas, United States
Institute for Drug Development, San Antonio, Texas, United States