⭐️⭐️⭐️⭐️⭐️ "A total no brainer"

⭐️⭐️⭐️⭐️⭐️ "Love this, so easy."

Spots is the easy way to track your skin, mole and cancer changes.

Spots Global Cancer Trial Database for Study of Trastuzumab Deruxtecan (T-DXd) vs Investigator's Choice Chemotherapy in HER2-low, Hormone Receptor Positive, Metastatic Breast Cancer

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Study of Trastuzumab Deruxtecan (T-DXd) vs Investigator's Choice Chemotherapy in HER2-low, Hormone Receptor Positive, Metastatic Breast Cancer

Official Title: A Phase 3, Randomized, Multi-center, Open-label Study of Trastuzumab Deruxtecan (T-DXd) Versus Investigator's Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Breast Cancer Patients Whose Disease Has Progressed on Endocrine Therapy in the Metastatic Setting (DESTINY-Breast06)

Study ID: NCT04494425

Study Description

Brief Summary: This study will evaluate the efficacy, safety and tolerability of trastuzumab deruxtecan compared with investigator's choice chemotherapy in human epidermal growth factor receptor (HER)2-low, hormone receptor (HR) positive breast cancer patients whose disease has progressed on endocrine therapy in the metastatic setting.

Detailed Description: Eligible patients will be those patients who have had disease progression on at least 2 previous lines of endocrine therapies given for the treatment of metastatic disease or disease progression within 6 months of starting first line treatment for metastatic disease with an endocrine therapy combined with a CDK4/6 inhibitor. All patients must have historically confirmed HR positive (either estrogen receptor and/or progesterone receptor positive), HER2-low (defined as IHC2+/ISH- and IHC 1+) or HER2 IHC \>0 \<1+ expression, as determined by central laboratory testing results, advanced or metastatic breast cancer. The study aims to evaluate the efficacy, safety and tolerability of trastuzumab deruxtecan compared with investigator's choice chemotherapy. This study aims to see if trastuzumab deruxtecan allows patients to live longer without the cancer getting worse, or simply to live longer, compared to patients receiving standard of care chemotherapy. This study is also looking to see how the treatment and the cancer affects patients' quality of life.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Research Site, Scottsdale, Arizona, United States

Research Site, Springdale, Arkansas, United States

Research Site, Duarte, California, United States

Research Site, Los Angeles, California, United States

Research Site, Aurora, Colorado, United States

Research Site, Lakewood, Colorado, United States

Research Site, Washington, District of Columbia, United States

Research Site, Jacksonville, Florida, United States

Research Site, Kansas City, Kansas, United States

Research Site, Louisville, Kentucky, United States

Research Site, Bethesda, Maryland, United States

Research Site, Boston, Massachusetts, United States

Research Site, Detroit, Michigan, United States

Research Site, Rochester, Minnesota, United States

Research Site, Saint Louis, Missouri, United States

Research Site, Summit, New Jersey, United States

Research Site, Westbury, New York, United States

Research Site, Columbus, Ohio, United States

Research Site, Pittsburgh, Pennsylvania, United States

Research Site, Nashville, Tennessee, United States

Research Site, Austin, Texas, United States

Research Site, Dallas, Texas, United States

Research Site, Houston, Texas, United States

Research Site, Houston, Texas, United States

Research Site, Norfolk, Virginia, United States

Research Site, Seattle, Washington, United States

Research Site, Madison, Wisconsin, United States

Research Site, Buenos Aires, , Argentina

Research Site, Caba, , Argentina

Research Site, Caba, , Argentina

Research Site, Caba, , Argentina

Research Site, Ciudad de Buenos Aires, , Argentina

Research Site, Cordoba, , Argentina

Research Site, La Plata, , Argentina

Research Site, Mar del Plata, , Argentina

Research Site, Rosario, , Argentina

Research Site, Rosario, , Argentina

Research Site, Adelaide, , Australia

Research Site, Birtinya, , Australia

Research Site, Darlinghurst, , Australia

Research Site, Murdoch, , Australia

Research Site, South Brisbane, , Australia

Research Site, St Leonards, , Australia

Research Site, Waratah, , Australia

Research Site, Graz, , Austria

Research Site, Innsbruck, , Austria

Research Site, Anderlecht, , Belgium

Research Site, Bruxelles, , Belgium

Research Site, Charleroi, , Belgium

Research Site, Edegem, , Belgium

Research Site, Gent, , Belgium

Research Site, Leuven, , Belgium

Research Site, Liège, , Belgium

Research Site, Namur, , Belgium

Research Site, Roeselare, , Belgium

Research Site, Sint-Niklaas, , Belgium

Research Site, Barretos, , Brazil

Research Site, Belo Horizonte, , Brazil

Research Site, Natal, , Brazil

Research Site, Porto Alegre, , Brazil

Research Site, Porto Alegre, , Brazil

Research Site, Rio de Janeiro, , Brazil

Research Site, Sao Paulo, , Brazil

Research Site, Sorocaba, , Brazil

Research Site, São Paulo, , Brazil

Research Site, Calgary, Alberta, Canada

Research Site, Edmonton, Alberta, Canada

Research Site, Vancouver, British Columbia, Canada

Research Site, Toronto, CA, Canada

Research Site, London, Ontario, Canada

Research Site, Toronto, Ontario, Canada

Research Site, Toronto, Ontario, Canada

Research Site, Montreal, Quebec, Canada

Research Site, Montreal, Quebec, Canada

Research Site, Sherbrooke, Quebec, Canada

Research Site, Baoding, , China

Research Site, Beijing, , China

Research Site, Beijing, , China

Research Site, Changchun, , China

Research Site, Changsha, , China

Research Site, Changsha, , China

Research Site, Dalian, , China

Research Site, Foshan, , China

Research Site, Fuzhou, , China

Research Site, Guangzhou, , China

Research Site, Guangzhou, , China

Research Site, Guangzhou, , China

Research Site, Hangzhou, , China

Research Site, Hangzhou, , China

Research Site, Hangzhou, , China

Research Site, Harbin, , China

Research Site, Hefei, , China

Research Site, Jinan, , China

Research Site, Linyi, , China

Research Site, Nanchang, , China

Research Site, Nanchang, , China

Research Site, Nanjing, , China

Research Site, Nanjing, , China

Research Site, Nanning, , China

Research Site, Shanghai, , China

Research Site, Shenyang, , China

Research Site, Tianjin, , China

Research Site, Urumqi, , China

Research Site, Wuhan, , China

Research Site, Xi'an, , China

Research Site, Xi'an, , China

Research Site, Zhengzhou, , China

Research Site, Aalborg, , Denmark

Research Site, Copenhagen Ø, , Denmark

Research Site, Odense C, , Denmark

Research Site, Vejle, , Denmark

Research Site, Avignon Cedex 09, , France

Research Site, Besançon, , France

Research Site, Bordeaux, , France

Research Site, Brest, , France

Research Site, Caen Cedex 05, , France

Research Site, Dijon, , France

Research Site, Le Mans, , France

Research Site, Marseille, , France

Research Site, Montpellier, , France

Research Site, Nice, , France

Research Site, Paris, , France

Research Site, Pierre Benite, , France

Research Site, Plerin SUR MER, , France

Research Site, Rennes, , France

Research Site, Saint Herblain Cedex, , France

Research Site, Saint-cloud, , France

Research Site, Tours, , France

Research Site, Villejuif Cedex, , France

Research Site, Berlin, , Germany

Research Site, Dresden, , Germany

Research Site, Freiburg, , Germany

Research Site, Hannover, , Germany

Research Site, München, , Germany

Research Site, München, , Germany

Research Site, Münster, , Germany

Research Site, Velbert, , Germany

Research Site, Budapest, , Hungary

Research Site, Budapest, , Hungary

Research Site, Budapest, , Hungary

Research Site, Győr, , Hungary

Research Site, Kecskemét, , Hungary

Research Site, Nyíregyháza, , Hungary

Research Site, Szolnok, , Hungary

Research Site, Tatabánya, , Hungary

Research Site, Bengaluru, , India

Research Site, Calicut, , India

Research Site, Kolkata, , India

Research Site, Marg Jaipur, , India

Research Site, New Delhi, , India

Research Site, New Delhi, , India

Research Site, New Delhi, , India

Research Site, New Delhi, , India

Research Site, Surat, , India

Research Site, Thiruvananthapuram, , India

Research Site, Haifa, , Israel

Research Site, Jerusalem, , Israel

Research Site, Jerusalem, , Israel

Research Site, Kfar-Saba, , Israel

Research Site, Petah Tikva, , Israel

Research Site, Ramat Gan, , Israel

Research Site, Tel-Aviv, , Israel

Research Site, Aviano, , Italy

Research Site, Bergamo, , Italy

Research Site, Candiolo, , Italy

Research Site, Cona, , Italy

Research Site, Genova, , Italy

Research Site, Livorno, , Italy

Research Site, Messina, , Italy

Research Site, Milano, , Italy

Research Site, Milan, , Italy

Research Site, Napoli, , Italy

Research Site, Padova, , Italy

Research Site, Parma, , Italy

Research Site, Prato, , Italy

Research Site, Tricase, Lecce, , Italy

Research Site, Udine, , Italy

Research Site, Akashi-shi, , Japan

Research Site, Bunkyo-ku, , Japan

Research Site, Chiba-shi, , Japan

Research Site, Chuo-ku, , Japan

Research Site, Fukuoka-shi, , Japan

Research Site, Gifu-shi, , Japan

Research Site, Hidaka-shi, , Japan

Research Site, Hiroshima-shi, , Japan

Research Site, Isehara, , Japan

Research Site, Kagoshima-shi, , Japan

Research Site, Kashiwa, , Japan

Research Site, Kawasaki-shi, , Japan

Research Site, Kitaadachi-gun, , Japan

Research Site, Koto-ku, , Japan

Research Site, Matsuyama-shi, , Japan

Research Site, Nagoya, , Japan

Research Site, Naha-shi, , Japan

Research Site, Niigata-shi, , Japan

Research Site, Nishinomiya-shi, , Japan

Research Site, Okayama-shi, , Japan

Research Site, Osaka-shi, , Japan

Research Site, Osakasayama-shi, , Japan

Research Site, Sagamihara-shi, , Japan

Research Site, Sapporo-shi, , Japan

Research Site, Shinagawa-ku, , Japan

Research Site, Shinjuku-ku, , Japan

Research Site, Shizuoka, , Japan

Research Site, Tsu-shi, , Japan

Research Site, Yokohama-shi, , Japan

Research Site, Daegu, , Korea, Republic of

Research Site, Goyang-si, , Korea, Republic of

Research Site, Incheon, , Korea, Republic of

Research Site, Seongnam-si, , Korea, Republic of

Research Site, Seoul, , Korea, Republic of

Research Site, Seoul, , Korea, Republic of

Research Site, Seoul, , Korea, Republic of

Research Site, Seoul, , Korea, Republic of

Research Site, Seoul, , Korea, Republic of

Research Site, Alc. Cuauhtémoc, , Mexico

Research Site, Guadalajara Jalisco, , Mexico

Research Site, Guadalajra, , Mexico

Research Site, Mexico City, , Mexico

Research Site, Mexico City, , Mexico

Research Site, Mexico, D.F., , Mexico

Research Site, Monterrey, , Mexico

Research Site, México, , Mexico

Research Site, Nuevo Leon, , Mexico

Research Site, Amsterdam, , Netherlands

Research Site, Breda, , Netherlands

Research Site, Hengelo, , Netherlands

Research Site, Leeuwarden, , Netherlands

Research Site, Rotterdam, , Netherlands

Research Site, Sittard-Geleen, , Netherlands

Research Site, Bydgoszcz, , Poland

Research Site, Koszalin, , Poland

Research Site, Kraków, , Poland

Research Site, Rzeszów, , Poland

Research Site, Warszawa, , Poland

Research Site, Wroclaw, , Poland

Research Site, Łódź, , Poland

Research Site, Lisboa, , Portugal

Research Site, Lisboa, , Portugal

Research Site, Lisboa, , Portugal

Research Site, Krasnodar, , Russian Federation

Research Site, Moscow, , Russian Federation

Research Site, Moscow, , Russian Federation

Research Site, Moscow, , Russian Federation

Research Site, Moscow, , Russian Federation

Research Site, Saint Petersburg, , Russian Federation

Research Site, Saint Petersburg, , Russian Federation

Research Site, Saint-Petersburg, , Russian Federation

Research Site, Sankt-Peterburg, , Russian Federation

Research Site, Yaroslavl, , Russian Federation

Research Site, Ar Riyāḑ, , Saudi Arabia

Research Site, Dammam, , Saudi Arabia

Research Site, Jeddah, , Saudi Arabia

Research Site, Jeddah, , Saudi Arabia

Research Site, Riyadh, , Saudi Arabia

Research Site, Riyadh, , Saudi Arabia

Research Site, Bukit Merah, , Singapore

Research Site, Singapore, , Singapore

Research Site, Singapore, , Singapore

Research Site, Singapore, , Singapore

Research Site, Singapore, , Singapore

Research Site, Barcelona, , Spain

Research Site, Barcelona, , Spain

Research Site, Barcelona, , Spain

Research Site, Cordoba, , Spain

Research Site, El Palmar, , Spain

Research Site, La Coruña, , Spain

Research Site, Madrid, , Spain

Research Site, Madrid, , Spain

Research Site, Madrid, , Spain

Research Site, San Sebastián, , Spain

Research Site, Sevilla, , Spain

Research Site, Valencia, , Spain

Research Site, Göteborg, , Sweden

Research Site, Stockholm, , Sweden

Research Site, Uppsala, , Sweden

Research Site, Växjö, , Sweden

Research Site, Örebro, , Sweden

Research Site, Taichung, , Taiwan

Research Site, Tainan, , Taiwan

Research Site, Tainan, , Taiwan

Research Site, Taipei, , Taiwan

Research Site, Taipei, , Taiwan

Research Site, Taipei, , Taiwan

Research Site, Taipei, , Taiwan

Research Site, Tao-Yuan, , Taiwan

Research Site, Cambridge, , United Kingdom

Research Site, Cardiff, , United Kingdom

Research Site, Edinburgh, , United Kingdom

Research Site, Guildford, , United Kingdom

Research Site, Leeds, , United Kingdom

Research Site, London, , United Kingdom

Research Site, Manchester, , United Kingdom

Research Site, Northwood, , United Kingdom

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

Logo

Take Control of Your Skin and Body Changes Today.

Try out Spots for free, set up only takes 2 mins.

spots app storespots app store

Join others from around the world: