Spots Global Cancer Trial Database for A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy
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Trial Identification
Brief Title: A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy
Official Title: A Phase III, Open-label, Randomised, Multicentre Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer Without Actionable Genomic Alterations, and Whose Disease Has Progressed On or After Prior Anti-PD-(L)1 Therapy and Platinum-based Chemotherapy: LATIFY
Study ID: NCT05450692
Study Description
Brief Summary: This study will assess the efficacy and safety of the combination of ceralasertib and durvalumab versus standard of care docetaxel in patients with locally advanced and metastatic NSCLC after progression on prior anti-PD-(L)1 therapy and platinum-based chemotherapy.
Detailed Description: This study will consist of two treatment arms (Groups A and B). Participants will be randomised in a 1:1 ratio to one of the two treatment groups: * Group A: Ceralasertib plus durvalumab combination therapy Each 28-day cycle will begin with ceralasertib administered orally followed by durvalumab administered intravenously. * Group B: Docetaxel monotherapy Each 21-day cycle will begin with the administration of docetaxel.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Research Site, Birmingham, Alabama, United States
Research Site, Birmingham, Alabama, United States
Research Site, Mobile, Alabama, United States
Research Site, Chandler, Arizona, United States
Research Site, Phoenix, Arizona, United States
Research Site, Tucson, Arizona, United States
Research Site, Cerritos, California, United States
Research Site, Los Alamitos, California, United States
Research Site, Los Angeles, California, United States
Research Site, Whittier, California, United States
Research Site, Greeley, Colorado, United States
Research Site, Jacksonville, Florida, United States
Research Site, Orlando, Florida, United States
Research Site, Atlanta, Georgia, United States
Research Site, Marietta, Georgia, United States
Research Site, Peoria, Illinois, United States
Research Site, Fort Wayne, Indiana, United States
Research Site, Lexington, Kentucky, United States
Research Site, Lexington, Kentucky, United States
Research Site, Louisville, Kentucky, United States
Research Site, Baltimore, Maryland, United States
Research Site, Bethesda, Maryland, United States
Research Site, Rockville, Maryland, United States
Research Site, Hattiesburg, Mississippi, United States
Research Site, Omaha, Nebraska, United States
Research Site, Jamaica, New York, United States
Research Site, Charlotte, North Carolina, United States
Research Site, Winston-Salem, North Carolina, United States
Research Site, Canton, Ohio, United States
Research Site, Cleveland, Ohio, United States
Research Site, Allentown, Pennsylvania, United States
Research Site, York, Pennsylvania, United States
Research Site, Providence, Rhode Island, United States
Research Site, Greenville, South Carolina, United States
Research Site, Houston, Texas, United States
Research Site, Kingwood, Texas, United States
Research Site, Spokane, Washington, United States
Research Site, Appleton, Wisconsin, United States
Research Site, Buenos Aires, , Argentina
Research Site, Cordoba, , Argentina
Research Site, Pergamino, , Argentina
Research Site, Rosario, , Argentina
Research Site, Rosario, , Argentina
Research Site, San Juan, , Argentina
Research Site, Viedma, , Argentina
Research Site, Elizabeth Vale, , Australia
Research Site, Lismore, , Australia
Research Site, Murdoch, , Australia
Research Site, Wendouree, , Australia
Research Site, Charleroi, , Belgium
Research Site, Libramont-Chevigny, , Belgium
Research Site, Roeselare, , Belgium
Research Site, Fortaleza, , Brazil
Research Site, Porto Alegre, , Brazil
Research Site, Salvador, , Brazil
Research Site, Sao Paulo, , Brazil
Research Site, Sao Paulo, , Brazil
Research Site, Vancouver, British Columbia, Canada
Research Site, London, Ontario, Canada
Research Site, Newmarket, Ontario, Canada
Research Site, Chicoutimi, Quebec, Canada
Research Site, Montreal, Quebec, Canada
Research Site, Montreal, Quebec, Canada
Research Site, Rimouski, Quebec, Canada
Research Site, Quebec, , Canada
Research Site, Baoding, , China
Research Site, Beijing, , China
Research Site, Beijing, , China
Research Site, Changsha, , China
Research Site, Changsha, , China
Research Site, Chengdu, , China
Research Site, Chongqing, , China
Research Site, Deyang, , China
Research Site, Ganzhou, , China
Research Site, Guangzhou, , China
Research Site, Hangzhou, , China
Research Site, Hefei, , China
Research Site, Jinan, , China
Research Site, Linyi, , China
Research Site, Nanchang, , China
Research Site, Nanjing, , China
Research Site, Nanning, , China
Research Site, Nashik, , China
Research Site, Qingdao, , China
Research Site, Taiyuan, , China
Research Site, Taiyuan, , China
Research Site, Tianjin, , China
Research Site, Tianjin, , China
Research Site, Wuhan, , China
Research Site, Wuhan, , China
Research Site, Wuhan, , China
Research Site, Xingtai, , China
Research Site, Yantai, , China
Research Site, Zhanjiang, , China
Research Site, Zhengzhou, , China
Research Site, Zhengzhou, , China
Research Site, Angers, , France
Research Site, Clamart Cedex, , France
Research Site, Clermont Ferrand, , France
Research Site, Creteil, , France
Research Site, Lyon, , France
Research Site, Montpellier, , France
Research Site, Nantes cedex 1, , France
Research Site, Paris, , France
Research Site, Pessac, , France
Research Site, Saint Herblain Cedex, , France
Research Site, Saint-Quentin cedex, , France
Research Site, Vantoux, , France
Research Site, Villefranche Sur Saone, , France
Research Site, Villejuif Cedex, , France
Research Site, Berlin, , Germany
Research Site, Freiburg, , Germany
Research Site, Gauting, , Germany
Research Site, Karlsruhe, , Germany
Research Site, Kempten, , Germany
Research Site, Löwenstein, , Germany
Research Site, Moers, , Germany
Research Site, Münster, , Germany
Research Site, Ulm, , Germany
Research Site, Hong Kong, , Hong Kong
Research Site, King's Park, , Hong Kong
Research Site, Tun Mun, , Hong Kong
Research Site, Budapest, , Hungary
Research Site, Székesfehérvár, , Hungary
Research Site, Törökbálint, , Hungary
Research Site, Bhubaneswar, , India
Research Site, Bhubaneswar, , India
Research Site, Jaipur, , India
Research Site, Jaipur, , India
Research Site, Mumbai, , India
Research Site, Pune, , India
Research Site, Surat, , India
Research Site, Cork, , Ireland
Research Site, Dublin 4, , Ireland
Research Site, Dublin, , Ireland
Research Site, Dublin, , Ireland
Research Site, Limerick, , Ireland
Research Site, Aviano, , Italy
Research Site, Catania, , Italy
Research Site, Livorno, , Italy
Research Site, Meldola, , Italy
Research Site, Milano, , Italy
Research Site, Monza, , Italy
Research Site, Napoli, , Italy
Research Site, Padova, , Italy
Research Site, Parma, , Italy
Research Site, Roma, , Italy
Research Site, Rozzano, , Italy
Research Site, Verona, , Italy
Research Site, Bunkyo-ku, , Japan
Research Site, Bunkyo-ku, , Japan
Research Site, Chuo-ku, , Japan
Research Site, Hiroshima-shi, , Japan
Research Site, Koto-ku, , Japan
Research Site, Kurashiki-shi, , Japan
Research Site, Kurume-shi, , Japan
Research Site, Matsuyama-shi, , Japan
Research Site, Nagasaki-shi, , Japan
Research Site, Nagoya-shi, , Japan
Research Site, Niigata-shi, , Japan
Research Site, Osaka-shi, , Japan
Research Site, Sakai-shi, , Japan
Research Site, Sapporo-shi, , Japan
Research Site, Sendai-shi, , Japan
Research Site, Sunto-gun, , Japan
Research Site, Toyoake-shi, , Japan
Research Site, Yokohama-shi, , Japan
Research Site, Yokohama-shi, , Japan
Research Site, Yokohama-shi, , Japan
Research Site, Cheongju-si, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Suwon, , Korea, Republic of
Research Site, Heerlen, , Netherlands
Research Site, Rotterdam, , Netherlands
Research Site, Tilburg, , Netherlands
Research Site, Zutphens, , Netherlands
Research Site, Gdansk, , Poland
Research Site, Gdańsk, , Poland
Research Site, Krakow, , Poland
Research Site, Kraków, , Poland
Research Site, Poznan, , Poland
Research Site, Skórzewo, , Poland
Research Site, Toruń, , Poland
Research Site, Bucuresti, , Romania
Research Site, Bucuresti, , Romania
Research Site, Cluj-Napoca, , Romania
Research Site, Cluj-Napoca, , Romania
Research Site, Constanta, , Romania
Research Site, Craiova, , Romania
Research Site, Craiova, , Romania
Research Site, Floresti, , Romania
Research Site, Oradea, , Romania
Research Site, Timisoara, , Romania
Research Site, Timisoara, , Romania
Research Site, Belgrade, , Serbia
Research Site, Belgrade, , Serbia
Research Site, Belgrad, , Serbia
Research Site, Kragujevac, , Serbia
Research Site, A Coruña, , Spain
Research Site, A Coruña, , Spain
Research Site, Barcelona, , Spain
Research Site, Barcelona, , Spain
Research Site, Barcelona, , Spain
Research Site, Castello de la Plana, , Spain
Research Site, Cordoba, , Spain
Research Site, Hospitalet deLlobregat, , Spain
Research Site, Madrid, , Spain
Research Site, Madrid, , Spain
Research Site, Majadahonda, , Spain
Research Site, Malaga, , Spain
Research Site, Orense, , Spain
Research Site, Palma de Mallorca, , Spain
Research Site, Pamplona, , Spain
Research Site, Pozuelo de Alarcon, , Spain
Research Site, Sabadell, , Spain
Research Site, Servilla, , Spain
Research Site, Zaragoza, , Spain
Research Site, Taichung, , Taiwan
Research Site, Taichung, , Taiwan
Research Site, Taichung, , Taiwan
Research Site, Tainan, , Taiwan
Research Site, Taipei City, , Taiwan
Research Site, Taipei, , Taiwan
Research Site, Taoyuan City, , Taiwan
Research Site, Yunlin, , Taiwan
Research Site, Bristol, , United Kingdom
Research Site, Guildford, , United Kingdom
Research Site, Stevenage, , United Kingdom
Research Site, Sutton, , United Kingdom
Research Site, Wirral, , United Kingdom
Contact Details
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