⭐️⭐️⭐️⭐️⭐️ "A total no brainer"

⭐️⭐️⭐️⭐️⭐️ "Love this, so easy."

Spots is the easy way to track your skin, mole and cancer changes.

Spots Global Cancer Trial Database for Durvalumab Treatment in Combination With Chemotherapy and Bevacizumab, Followed by Maintenance Durvalumab, Bevacizumab and Olaparib Treatment in Advanced Ovarian Cancer Patients

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Durvalumab Treatment in Combination With Chemotherapy and Bevacizumab, Followed by Maintenance Durvalumab, Bevacizumab and Olaparib Treatment in Advanced Ovarian Cancer Patients

Official Title: A Phase III Randomised, Double-Blind, Placebo-Controlled, Multicentre Study of Durvalumab in Combination With Chemotherapy and Bevacizumab, Followed by Maintenance Durvalumab, Bevacizumab and Olaparib in Newly Diagnosed Advanced Ovarian Cancer Patients (DUO-O).

Study ID: NCT03737643

Study Description

Brief Summary: This is a Phase III randomised, double-blind, multi-centre study to evaluate the efficacy and safety of durvalumab in combination with standard of care platinum based chemotherapy and bevacizumab followed by maintenance durvalumab and bevacizumab or durvalumab, bevacizumab and olaparib in patients with newly diagnosed advanced ovarian cancer.

Detailed Description: Eligible patients will be those patients with newly diagnosed, histologically confirmed advanced (Fédération Internationale de Gynécologie et d'Obstétrique \[FIGO\] Stage III-IV) ovarian, primary peritoneal cancer and/or fallopian-tube cancer. All patients should be candidates for cytoreductive surgery which could be conducted as immediate upfront primary surgery following diagnosis or can be conducted after initiation of platinum based neoadjuvant chemotherapy. All patients should be eligible to start first line platinum based chemotherapy in combination with bevacizumab. The study aims to evaluate the efficacy and safety of standard of care (SoC) platinum-based chemotherapy and bevacizumab followed by maintenance bevacizumab either as monotherapy, or in combination with durvalumab, or in combination with durvalumab and olaparib. Therefore, this study aims to see which combination allows patients to live longer without the cancer coming back or getting worse. The study is also looking to see which combination makes patients live longer and how the treatment and the cancer affects their quality of life.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

Research Site, Foothill Ranch, California, United States

Research Site, Los Angeles, California, United States

Research Site, Orange, California, United States

Research Site, San Francisco, California, United States

Research Site, Tampa, Florida, United States

Research Site, Augusta, Georgia, United States

Research Site, Hinsdale, Illinois, United States

Research Site, Indianapolis, Indiana, United States

Research Site, Towson, Maryland, United States

Research Site, Detroit, Michigan, United States

Research Site, Springfield, Missouri, United States

Research Site, Middletown, New Jersey, United States

Research Site, Montvale, New Jersey, United States

Research Site, Albany, New York, United States

Research Site, New York, New York, United States

Research Site, Uniondale, New York, United States

Research Site, Durham, North Carolina, United States

Research Site, Cleveland, Ohio, United States

Research Site, Dayton, Ohio, United States

Research Site, Hilliard, Ohio, United States

Research Site, Tulsa, Oklahoma, United States

Research Site, Lancaster, Pennsylvania, United States

Research Site, Philadelphia, Pennsylvania, United States

Research Site, Philadelphia, Pennsylvania, United States

Research Site, Pittsburgh, Pennsylvania, United States

Research Site, Salt Lake City, Utah, United States

Research Site, Graz, , Austria

Research Site, Innsbruck, , Austria

Research Site, Linz, , Austria

Research Site, Wien, , Austria

Research Site, Aalst, , Belgium

Research Site, Leuven, , Belgium

Research Site, Namur, , Belgium

Research Site, Oostende, , Belgium

Research Site, Sint-Niklaas, , Belgium

Research Site, Barretos, , Brazil

Research Site, Florianópolis, , Brazil

Research Site, Fortaleza, , Brazil

Research Site, Londrina, , Brazil

Research Site, Porto Alegre, , Brazil

Research Site, Porto Alegre, , Brazil

Research Site, Rio de Janeiro, , Brazil

Research Site, Sao Paulo, , Brazil

Research Site, São Paulo, , Brazil

Research Site, Burgas, , Bulgaria

Research Site, Plovdiv, , Bulgaria

Research Site, Sofia, , Bulgaria

Research Site, Varna, , Bulgaria

Research Site, Calgary, Alberta, Canada

Research Site, Barrie, Ontario, Canada

Research Site, Sudbury, Ontario, Canada

Research Site, Toronto, Ontario, Canada

Research Site, Montreal, Quebec, Canada

Research Site, Montreal, Quebec, Canada

Research Site, Montreal, Quebec, Canada

Research Site, Rimouski, Quebec, Canada

Research Site, Quebec, , Canada

Research Site, Beijing, , China

Research Site, Beijing, , China

Research Site, Bengbu, , China

Research Site, Changchun, , China

Research Site, Changsha, , China

Research Site, Changsha, , China

Research Site, Chengdu, , China

Research Site, Chongqing, , China

Research Site, Dalian, , China

Research Site, Guangzhou, , China

Research Site, Guangzhou, , China

Research Site, Hangzhou, , China

Research Site, Hangzhou, , China

Research Site, Harbin, , China

Research Site, Hefei, , China

Research Site, Jinhua, , China

Research Site, Kunming, , China

Research Site, Lanzhou, , China

Research Site, Luzhou, , China

Research Site, Nan Chong, , China

Research Site, Nanjing, , China

Research Site, Nanning, , China

Research Site, Nantong, , China

Research Site, Shanghai, , China

Research Site, Shanghai, , China

Research Site, Wuhan, , China

Research Site, Wuhan, , China

Research Site, Xi'an, , China

Research Site, Zhengzhou, , China

Research Site, Zhengzhou, , China

Research Site, Zhuhai, , China

Research Site, Aalborg, , Denmark

Research Site, Aarhus N, , Denmark

Research Site, Odense C, , Denmark

Research Site, Roskilde, , Denmark

Research Site, Vejle, , Denmark

Research Site, Kuopio, , Finland

Research Site, Oulu, , Finland

Research Site, Turku, , Finland

Research Site, Besançon, , France

Research Site, Bordeaux, , France

Research Site, Limoges Cedex, , France

Research Site, Lyon Cedex 08, , France

Research Site, Marseille, , France

Research Site, Nantes, , France

Research Site, Paris Cedex 14, , France

Research Site, Paris, , France

Research Site, Paris, , France

Research Site, Saint Herblain Cedex, , France

Research Site, Vandoeuvre les Nancy, , France

Research Site, Bad Homburg, , Germany

Research Site, Berlin, , Germany

Research Site, Bielefeld, , Germany

Research Site, Bonn, , Germany

Research Site, Brandenburg, , Germany

Research Site, Dresden, , Germany

Research Site, Düsseldorf, , Germany

Research Site, Essen, , Germany

Research Site, Essen, , Germany

Research Site, Esslingen am Neckar, , Germany

Research Site, Frankfurt, , Germany

Research Site, Freiburg, , Germany

Research Site, Fürth, , Germany

Research Site, Greifswald, , Germany

Research Site, Gütersloh, , Germany

Research Site, Hamburg, , Germany

Research Site, Hamburg, , Germany

Research Site, Hamburg, , Germany

Research Site, Hannover, , Germany

Research Site, Hannover, , Germany

Research Site, Jena, , Germany

Research Site, Karlsruhe, , Germany

Research Site, Karlsruhe, , Germany

Research Site, Kassel, , Germany

Research Site, Kiel, , Germany

Research Site, Köln, , Germany

Research Site, Leipzig, , Germany

Research Site, Ludwigsburg, , Germany

Research Site, Lübeck, , Germany

Research Site, Mainz, , Germany

Research Site, Mannheim, , Germany

Research Site, München, , Germany

Research Site, Offenbach am Main, , Germany

Research Site, Oldenburg, , Germany

Research Site, Rosenheim, , Germany

Research Site, Rostock, , Germany

Research Site, Saalfeld, , Germany

Research Site, Schweinfurt, , Germany

Research Site, Tübingen, , Germany

Research Site, Ulm, , Germany

Research Site, Worms, , Germany

Research Site, Budapest, , Hungary

Research Site, Budapest, , Hungary

Research Site, Debrecen, , Hungary

Research Site, Győr, , Hungary

Research Site, Kaposvár, , Hungary

Research Site, Szeged, , Hungary

Research Site, Zalaegerszeg, , Hungary

Research Site, Brescia, , Italy

Research Site, Lecce, , Italy

Research Site, Lecco, , Italy

Research Site, Milano, , Italy

Research Site, Milano, , Italy

Research Site, Mirano, , Italy

Research Site, Napoli, , Italy

Research Site, Reggio Calabria, , Italy

Research Site, Reggio Emilia, , Italy

Research Site, Roma, , Italy

Research Site, Torino, , Italy

Research Site, Torino, , Italy

Research Site, Fukuoka-shi, , Japan

Research Site, Kashiwa-shi, , Japan

Research Site, Kobe-shi, , Japan

Research Site, Koto-ku, , Japan

Research Site, Kurume-shi, , Japan

Research Site, Kyoto-shi, , Japan

Research Site, Minato-ku, , Japan

Research Site, Nagoya-shi, , Japan

Research Site, Niigata-shi, , Japan

Research Site, Okayama-shi, , Japan

Research Site, Sapporo-shi, , Japan

Research Site, Sendai-shi, , Japan

Research Site, Shinjuku-ku, , Japan

Research Site, Sunto-gun, , Japan

Research Site, Toyoake-shi, , Japan

Research Site, Goyang-si, , Korea, Republic of

Research Site, Seongnam-si, , Korea, Republic of

Research Site, Seoul, , Korea, Republic of

Research Site, Seoul, , Korea, Republic of

Research Site, Seoul, , Korea, Republic of

Research Site, Suwon-si, , Korea, Republic of

Research Site, Bellavista, , Peru

Research Site, La Libertad, , Peru

Research Site, Lima, , Peru

Research Site, Lima, , Peru

Research Site, Lima, , Peru

Research Site, Lima, , Peru

Research Site, San Isidro, , Peru

Research Site, Gdynia, , Poland

Research Site, Szczecin, , Poland

Research Site, Warszawa, , Poland

Research Site, Warszawa, , Poland

Research Site, Łódź, , Poland

Research Site, Floresti, , Romania

Research Site, Córdoba, , Spain

Research Site, Madrid, , Spain

Research Site, Madrid, , Spain

Research Site, Madrid, , Spain

Research Site, Madrid, , Spain

Research Site, Terrassa(Barcelona), , Spain

Research Site, Vigo, , Spain

Research Site, Adana, , Turkey

Research Site, Ankara, , Turkey

Research Site, Ankara, , Turkey

Research Site, Istanbul, , Turkey

Research Site, Istanbul, , Turkey

Research Site, Izmir, , Turkey

Contact Details

Name: Philipp Harter

Affiliation: European Network of Gynaecological Oncological Trial Groups (ENGOT)

Role: PRINCIPAL_INVESTIGATOR

Name: Carol Aghajanian

Affiliation: GOG

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

Logo

Take Control of Your Skin and Body Changes Today.

Try out Spots for free, set up only takes 2 mins.

spots app storespots app store

Join others from around the world: