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Spots Global Cancer Trial Database for A Study to Evaluate the Safety, Pharmacokinetics and Clinical Activity of RO6870810 and Atezolizumab (PD-L1 Antibody) in Participants With Advanced Ovarian Cancer or Triple Negative Breast Cancer

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Trial Identification

Brief Title: A Study to Evaluate the Safety, Pharmacokinetics and Clinical Activity of RO6870810 and Atezolizumab (PD-L1 Antibody) in Participants With Advanced Ovarian Cancer or Triple Negative Breast Cancer

Official Title: Open Label, Dose Finding and Expansion Phase IB Study to Evaluate the Safety, Pharmacokinetics and Clinical Activity of RO6870810 and Atezolizumab (Pd L1 Antibody) in Pateints With Advanced Ovarian Cancer or Triple Negative Breast Cancer

Study ID: NCT03292172

Study Description

Brief Summary: This is Phase IB, open label, non-randomized study designed to investigate the dose, safety, pharmacokinetics and anti-tumor activity of RO6870810 in combination with a fixed dose of atezolizumab. The study consists of four groups, Group 1 (Dose Escalation Group) and Group 2 (Sequential Dose Group), and Groups 3 and 4 (Expansion Groups), which will further evaluate the safety, pharmacokinetic, pharmacodynamic and preliminary clinical activity in patients with triple negaive breast cancer and/or ovarian cancer.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Dana Farber Cancer Institute, Boston, Massachusetts, United States

Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, United States

Sarah Cannon Res Inst; TN Onc, Nashville, Tennessee, United States

St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia

Peter MacCallum Cancer Centre; Medical Oncology, Melbourne, Victoria, Australia

University Health Network; Princess Margaret Hospital; Medical Oncology Dept, Toronto, Ontario, Canada

Rigshospitalet; Onkologisk Klinik, København Ø, , Denmark

Western General Hospital, Edinburgh, , United Kingdom

Guys and St Thomas NHS Foundation Trust, Guys Hospital, London, , United Kingdom

The Christie, Manchester, , United Kingdom

Churchill Hospital, Oxford, , United Kingdom

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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