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Brief Title: A Study of SHR-1210 in Combination With Apatinib or Chemotherapy in Subjects With Advanced PLC or BTC
Official Title: A Phase 2 Study of SHR-1210 (PD-1 Antibody) in Combination With Apatinib or Chemotherapy (FOLFOX4 or GEMOX) in Subjects With Advanced Primary Liver Cancer(PLC)or Biliary Tract Carcinoma (BTC)
Study ID: NCT03092895
Brief Summary: This an open-label,Non-Randominzed Phase 2 study to evaluate the Safety and Tolerability of SHR-1210 in combination with Apatinib or chemotherapy (FOLFOX4 or GEMOX regimen) in subjects with Advanced PLC.or BTC Participants with advanced PLC who failed or intolerable to prior systemic therapy will be treated with SHR-1210 plus Apatinib; Participants with advanced PLC or BTC who have never received prior systemic therapy will be treated with SHR-1210 plus FOLFOX4 or GEMOX regimen.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
The Second Affiliated Hospital Of Anhui Medical University, Hefei, Anhui, China
Hunan Cancer Hospital, Hunan, Changsha, China
Cancer Hospital of Henan province, Zhengzhou, Henan, China
81 Hospital Nanjing, Nanjing, Jiangsu, China
The First Affiliated Hospital of Nanchang University, Jiangxi, Nanchang, China
Zhongshan Hospital, Shanghai, Shanghai, China
Fudan University Shanghai Cancer Center, Shanghai, Shanghai, China