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Brief Title: Nivolumab Combined With Ipilimumab Versus Sunitinib in Previously Untreated Advanced or Metastatic Renal Cell Carcinoma (CheckMate 214)
Official Title: A Phase 3, Randomized, Open-Label Study of Nivolumab Combined With Ipilimumab Versus Sunitinib Monotherapy in Subjects With Previously Untreated, Advanced or Metastatic Renal Cell Carcinoma
Study ID: NCT02231749
Brief Summary: The purpose of this study is to compare the objective response rate, progression free survival and the overall survival of Nivolumab combined with Ipilimumab to Sunitinib monotherapy in patients with previously untreated Renal Cell Cancer.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Local Institution - 0006, Duarte, California, United States
Local Institution - 0057, La Jolla, California, United States
Local Institution - 0044, Los Angeles, California, United States
Local Institution - 0035, Los Angeles, California, United States
Local Institution - 0067, Stanford, California, United States
Local Institution - 0138, New Haven, Connecticut, United States
Local Institution - 0034, Washington, District of Columbia, United States
Local Institution - 0049, Tampa, Florida, United States
Local Institution - 0068, Atlanta, Georgia, United States
Local Institution - 0038, Indianapolis, Indiana, United States
Local Institution - 0042, Iowa City, Iowa, United States
Local Institution - 0163, Fairway, Kansas, United States
Local Institution - 0048, Baltimore, Maryland, United States
Local Institution - 0004, Baltimore, Maryland, United States
Local Institution - 0135, Boston, Massachusetts, United States
Local Institution - 0110, Boston, Massachusetts, United States
Local Institution - 0161, Boston, Massachusetts, United States
Local Institution - 0173, Boston, Massachusetts, United States
Local Institution - 0046, Ann Arbor, Michigan, United States
Local Institution - 0043, Detroit, Michigan, United States
Local Institution - 0036, Buffalo, New York, United States
Local Institution - 0001, New York, New York, United States
Local Institution - 0008, Charlotte, North Carolina, United States
Local Institution - 0045, Durham, North Carolina, United States
Local Institution - 0007, Cleveland, Ohio, United States
Local Institution - 0164, Columbus, Ohio, United States
Local Institution - 0039, Portland, Oregon, United States
Local Institution - 0054, Allentown, Pennsylvania, United States
Local Institution - 0005, Philadelphia, Pennsylvania, United States
Local Institution - 0031, Pittsburgh, Pennsylvania, United States
Local Institution - 0055, Charleston, South Carolina, United States
Local Institution - 0159, Chattanooga, Tennessee, United States
Local Institution - 0066, Nashville, Tennessee, United States
Local Institution - 0056, Dallas, Texas, United States
Local Institution - 0032, Dallas, Texas, United States
Local Institution - 0003, Houston, Texas, United States
Local Institution - 0041, Seattle, Washington, United States
Local Institution - 0099, Berazategui, Buenos Aires, Argentina
Local Institution - 0098, Capital Federal, Buenos Aires, Argentina
Local Institution - 0139, Ciudad Autonoma De Buenos Aire, Buenos Aires, Argentina
Local Institution - 0095, San Miguel De Tucuman, Tucuman, Argentina
Local Institution - 0096, San Miguel de Tucuman, Tucuman, Argentina
Local Institution - 0097, Caba, , Argentina
Local Institution - 0100, Cordoba, , Argentina
Local Institution - 0073, Kogarah, New South Wales, Australia
Local Institution - 0070, Westmead, New South Wales, Australia
Local Institution - 0076, Herston, Queensland, Australia
Local Institution - 0075, Southport, Queensland, Australia
Local Institution - 0140, Elizabeth Vale, South Australia, Australia
Local Institution - 0072, Box Hill, Victoria, Australia
Local Institution - 0071, Clayton, Victoria, Australia
Local Institution - 0104, Nedlands, Western Australia, Australia
Local Institution - 0074, Murdoch, , Australia
Local Institution - 0108, Linz, , Austria
Local Institution - 0107, Wels, , Austria
Local Institution - 0109, Wien, , Austria
Local Institution - 0020, Gent, , Belgium
Local Institution - 0019, Leuven, , Belgium
Local Institution - 0152, Belo Horizonte, Minas Gerais, Brazil
Local Institution - 0150, Porto Alegre, RIO Grande DO SUL, Brazil
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Local Institution - 0149, Calgary, Alberta, Canada
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Local Institution - 0131, Moncton, New Brunswick, Canada
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Local Institution - 0051, Hradec Kralove, , Czechia
Local Institution - 0052, Olomouc, , Czechia
Local Institution - 0136, Aarhus N, , Denmark
Local Institution - 0158, Herlev, , Denmark
Local Institution - 0137, Odense, , Denmark
Local Institution - 0027, Helsinki, Uusimaa, Finland
Local Institution - 0028, Tampere, , Finland
Local Institution - 0170, Besançon, , France
Local Institution - 0062, Bordeaux, , France
Local Institution - 0169, La Roche-Sur-Yon Cedex 9, , France
Local Institution - 0060, Marseille Cedex 9, , France
Local Institution - 0063, Saint Herblain, , France
Local Institution - 0065, Strasbourg, , France
Local Institution - 0059, Toulouse Cedex 9, , France
Local Institution - 0058, Villejuif, , France
Local Institution - 0061, Paris, Île-de-France, France
Local Institution - 0125, Aachen, , Germany
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Local Institution - 0141, Frankfurt, , Germany
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Local Institution - 0130, Ulm, , Germany
Local Institution - 0184, Gyula, Békés, Hungary
Local Institution - 0083, Budapest, , Hungary
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Local Institution - 0084, Pecs, , Hungary
Local Institution - 0015, Wilton, Cork, Ireland
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Local Institution - 0120, Haifa, , Israel
Local Institution - 0117, Kfar Saba, , Israel
Local Institution - 0121, Petach Tikva, , Israel
Local Institution - 0118, Ramat-gan, , Israel
Local Institution - 0119, Zerifin, , Israel
Local Institution - 0022, Arezzo, , Italy
Local Institution - 0024, Meldola (fc), , Italy
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Local Institution - 0064, Napoli, , Italy
Local Institution - 0079, Padova, , Italy
Local Institution - 0025, Pavia, , Italy
Local Institution - 0026, Roma, , Italy
Local Institution - 0192, Akita-shi, Akita, Japan
Local Institution - 0209, Hirosaki-shi, Aomori, Japan
Local Institution - 0187, Chiba-shi, Chiba, Japan
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Local Institution - 0188, Sapporo-shi, Hokai-do, Japan
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Local Institution - 0205, Tsukuba-shi, Ibaraki, Japan
Local Institution - 0200, Morioka-shi, Iwate, Japan
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Local Institution - 0178, Seoul, , Korea, Republic of
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Local Institution - 0168, Mexico D.f., Distrito Federal, Mexico
Local Institution - 0171, Monterrey, Nuevo Leon, Mexico
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Local Institution - 0029, Amsterdam, , Netherlands
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Local Institution - 0030, Nijmegen, , Netherlands
Local Institution - 0093, Krakow, , Poland
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Local Institution - 0089, Barcelona, , Spain
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Local Institution - 0090, Sevilla, , Spain
Local Institution - 0134, Solna, , Sweden
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Local Institution - 0115, Ankara, , Turkey
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Local Institution - 0122, Istanbul, , Turkey
Local Institution - 0010, London, Greater London, United Kingdom
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Local Institution - 0077, London, , United Kingdom
Local Institution - 0021, Manchester, , United Kingdom
Local Institution - 0011, Northwood, , United Kingdom
Local Institution - 0012, Swansea, , United Kingdom
Name: Bristol-Myers Squibb
Affiliation: Bristol-Myers Squibb
Role: STUDY_DIRECTOR