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Spots Global Cancer Trial Database for Safety and Efficacy Study of CFI-402411 in Subjects With Advanced Solid Malignancies

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Trial Identification

Brief Title: Safety and Efficacy Study of CFI-402411 in Subjects With Advanced Solid Malignancies

Official Title: A First-In-Human, Phase 1/2 Study Of CFI-402411, a Hematopoietic Progenitor Kinase-1 (HPK1) Inhibitor, as a Single Agent and in Combination With Pembrolizumab in Subjects With Advanced Solid Malignancies

Study ID: NCT04521413

Study Description

Brief Summary: The purpose of this study is to test the safety of an investigational drug called CFI-402411 alone and in combination with pembrolizumab and to study its effects in patients with advanced solid tumors who have progressed following previous therapies.

Detailed Description: This study will be a first-in-human study evaluating the safety and tolerability of CFI-402411 in subjects with advanced solid malignancies, when CFI-402411 is administered as a single agent or in combination with pembrolizumab. CFI-402411 is an oral pill that blocks the function of HPK1. Blocking HPK1 could stimulate an immune response against the tumor in patients. This immune response could be further enhanced when combined with pembrolizumab. The data obtained from this study will determine the dose and schedule and subject selection for further clinical studies. Pre-clinical findings support further development of CFI-402411 as a novel anti-cancer agent, and the combination of CFI-402411 with pembrolizumab as a potential strategy to improve outcomes of subjects with advanced malignancies.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

University of California San Diego, La Jolla, California, United States

The Angeles Clinic, Los Angeles, California, United States

Yale Cancer Center, New Haven, Connecticut, United States

Florida Cancer Specialists, Sarasota, Florida, United States

START - Mid-West, Grand Rapids, Michigan, United States

SCRI - Nashville, Nashville, Tennessee, United States

MD Anderson, Houston, Texas, United States

START - San Antonio, San Antonio, Texas, United States

Virginia Cancer Specialist, Fairfax, Virginia, United States

Cross Cancer Institute, Edmonton, Alberta, Canada

The Ottawa Hospital, Ottawa, Ontario, Canada

Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Prince of Wales Hospital, Sha Tin, , Hong Kong

Contact Details

Name: Omid Hamid, Dr

Affiliation: The Angeles Clinic, Los Angeles

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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