Spots Global Cancer Trial Database for RT-01 Monotherapy and in Combination With Nivolumab in Patients With Advanced Solid Tumors

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Trial Identification

Brief Title: RT-01 Monotherapy and in Combination With Nivolumab in Patients With Advanced Solid Tumors

Official Title: An Open-label Clinical Study to Evaluate the Safety and Efficacy of Intravenous With and Without Intratumoral Oncolytic Virus Injection (RT-01) Combined With or Without Immune Checkpoint Inhibitors (Nivolumab) in the Treatment of Patients With Advanced Solid Tumors

Study ID: NCT05122572

Conditions

Advanced Solid Tumor

Interventions

Oncolytic Virus Injection (RT-01）

Study Description

Brief Summary: This is a single-arm, open-lable study to determine the safety, tolerability and preliminary efficacy of oncolytic virus injection (RT-01) combined with or without immune checkpoint inhibitors (Nivolumab) in the treatment of patients with advanced solid tumors.

Detailed Description: To evaluate the safety, tolerability, efficacy, immunoreactivity, immunogenicity, pharmacokinetics and virus shedding of RT-01 injection given via Intravenous with or without Intratumoral administration combined with immune checkpoint inhibitors Nivolumab in the treatment of patients with advanced solid tumors.