Spots Global Cancer Trial Database for Mirdametinib + BGB-3245 in Advanced Solid Tumors
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Trial Identification
Brief Title: Mirdametinib + BGB-3245 in Advanced Solid Tumors
Official Title: A Phase 1/2a Open-Label, Dose Escalation and Expansion Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of Mirdametinib in Combination With BGB-3245 in Patients With Advanced Solid Tumors
Study ID: NCT05580770
Conditions
Study Description
Brief Summary: A Phase 1/2a open-label, multicenter, dose escalation and expansion study of mirdametinib in combination with BGB-3245 in adult participants with histologically confirmed, advanced (American Joint Committee on Cancer (AJCC) Stage III or IV) metastatic or unresectable solid cancer that is refractory to or has progressed during or after at least 1 line of appropriate prior systemic anti-cancer therapy including chemotherapy, immunotherapy, or appropriate targeted therapy, or for which there is no treatment available, or prior standard of care therapy was not tolerated.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
UC San Diego Moores Cancer Center, La Jolla, California, United States
Yale-New Haven Hospital-Yale Cancer Center, New Haven, Connecticut, United States
Orlando Health Cancer Institute, Orlando, Florida, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States
Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States
Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas, Texas, United States
Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Calvary Mater Newcastle, Waratah, , Australia
Contact Details
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