Spots Global Cancer Trial Database for A Study of GRC 54276 in Participants With Advanced Solid Tumors and Lymphomas.
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Trial Identification
Brief Title: A Study of GRC 54276 in Participants With Advanced Solid Tumors and Lymphomas.
Official Title: A Phase 1, Open Label First In Human Study Investigating the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of HPK1 Inhibitor GRC 54276 Alone and in Combination With Anti-PD-1 Monoclonal Antibody Pembrolizumab or Anti-PD-L1 Atezolizumab in Subjects With Advanced Solid Tumors and Lymphomas.
Study ID: NCT05878691
Study Description
Brief Summary: This is first in human (FIH) study to a) evaluate the safety and tolerability profile of GRC54276, b) determine the maximum tolerated dose (MTD) and recommended Phase 2 doses (RP2D), and c) pharmacokinetic profile of GRC54276 alone and in combination with pembrolizumab or atezolizumab in participants with advanced solid tumors and lymphomas.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Carolina BioOncology Institute, Huntersville, North Carolina, United States
Froedtert & Medical College of Wisconsin - Froedtert Hospital - Clinical Cancer Center, Milwaukee, Wisconsin, United States
Hcg City Cancer Centre, Vijayawada, Andhra Pradesh, India
Mahatma Gandhi Cancer Hospital and Research Institute, Visakhapatnam, Andhra Pradesh, India
Artemis Hospital, Gurgaon, Haryana, India
Health Care Global Enterprises Ltd (HCG), Bangalore, Karnataka, India
Vydehi Hospital, Bangalore, Karnataka, India
Cytecare Hospitals Pvt Ltd., Bengaluru, Karnataka, India
Aster CMI Hospital, Bengaluru, Karnataka, India
Malabar Cancer Centre, Kannur, Kerala, India
Krupamayi Hospitals, Aurangabad, Maharashtra, India
PD Hinduja Hospital and Medical Research Centre, Mumbai, Maharashtra, India
HCG Manavata Cancer Centre, Nashik, Maharashtra, India
Sankalp Hospital, Nashik, Maharashtra, India
Bhaktivedanta Hospital and Research Institute, Thāne, Maharashtra, India
AIG Hospitals, (A unit of asian Institute of Gastroenterology), Hyderabad, Telangana, India
Basavatarakam Indo American Cancer Hospital Research Institute, Hyderabad, Telangana, India
Max Superspeciality Hospital, Delhi, , India
Contact Details
Name: Harsha Doddihal, MD
Affiliation: Glenmark Pharmaceuticals Ltd.
Role: STUDY_DIRECTOR
Name: Adam Y-Beltran, MD
Affiliation: Glenmark Pharmaceuticals Ltd.
Role: STUDY_DIRECTOR
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