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Brief Title: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of ADCT-901 in Participants With Selected Advanced Solid Tumors
Official Title: A Phase 1, Open-Label, Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of ADCT-901 as Monotherapy in Patients With Selected Advanced Solid Tumors
Study ID: NCT04972981
Brief Summary: The primary objectives of this study are to identify the recommended phase 2 dose (RP2D) and/or maximum tolerated dose (MTD), and to characterize the safety and the tolerability of ADCT-901.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Sarah Cannon at HealthONE, Denver, Colorado, United States
Yale Cancer Center, New Haven, Connecticut, United States
Emory University, Winship Cancer Institute, Atlanta, Georgia, United States
Northwestern University, Chicago, Illinois, United States
University Hospitals of Cleveland Medical Center (UHCMC), Cleveland, Ohio, United States
Sarah Cannon at University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
NEXT Oncology, San Antonio, Texas, United States
Institut Catala D'oncologia (ICO) - Hospital Duran I Reynals Location, Badalona, Barcelona, Spain
Hospital Universitari Vall D'hebron - Vall D'hebron Institut D'oncologia (VHIO), Barcelona, , Spain
(START) Madrid - Hospital Universitario Fundación Jiménez Díaz Location, Madrid, , Spain
Universidad Complutense de Madrid - Hospital Universitario 12 de Octubre, Madrid, , Spain
Imperial College Healthcare NHS Trust - St Mary's Hospital, London, England, United Kingdom
Sarah Cannon Research Institute (SCRI) - London (SCRI-UK), London, England, United Kingdom