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Spots Global Cancer Trial Database for A Study to Evaluate the Safety and Tolerability of BMS-986408 Alone and in Combination With Nivolumab or Nivolumab and Ipilimumab in Participants With Advanced Solid Tumors

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Trial Identification

Brief Title: A Study to Evaluate the Safety and Tolerability of BMS-986408 Alone and in Combination With Nivolumab or Nivolumab and Ipilimumab in Participants With Advanced Solid Tumors

Official Title: A Phase 1/2 Study of BMS-986408 Alone and in Combination With Nivolumab or With Nivolumab and Ipilimumab in Participants With Advanced Solid Tumors

Study ID: NCT05407675

Study Description

Brief Summary: The primary purpose of this study is to characterize the safety profile of BMS-986408 as monotherapy and in combination with nivolumab or nivolumab and ipilimumab to establish the maximum tolerated dose (MTD). The Recommended Phase 2 Dose (RP2D) that optimizes the pharmacokinetic/pharmacodynamic (PK/PD) relationship of BMS-986408 will also be determined.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Local Institution - 0010, Boston, Massachusetts, United States

Local Institution - 0001, Hackensack, New Jersey, United States

Local Institution - 0003, Houston, Texas, United States

Local Institution - 0007, Edmonton, Alberta, Canada

Local Institution - 0011, Hamilton, Ontario, Canada

Local Institution - 0005, Ottawa, Ontario, Canada

Local Institution - 0006, Toronto, Ontario, Canada

Local Institution - 0015, Bordeaux, Aquitaine, France

Local Institution - 0014, Villejuif, Paris, France

Local Institution - 0018, Marseille, , France

Local Institution - 0019, Toulouse, , France

Local Institution - 0024, Málaga, Andalucía, Spain

Local Institution - 0025, Madrid, Madrid, Comunidad De, Spain

Local Institution - 0022, Madrid, , Spain

Local Institution - 0023, Madrid, , Spain

Local Institution - 0021, st.Gallen, Sankt Gallen, Switzerland

Local Institution - 0012, Basel, , Switzerland

Local Institution - 0020, Genève, , Switzerland

Contact Details

Name: Bristol-Myers Squibb

Affiliation: Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

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